NLRP3

Gene Name		NLR family, pyrin domain containing 3
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol NLRP3 Inflammasome Complex
	Molecular Function	Protein Binding ATP Binding Peptidoglycan Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Negative Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1 Beta Production Interleukin-18 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Interleukin-1 Secretion Negative Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Defense Response To Virus Cellular Response To Lipopolysaccharide
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS		C-reactive protein ( 21300955) Fibrinogen ( 20031576) Word reading ( 23738518)
Protein-protein Interactions		3 interactors: CARD8 FAF1 PYCARD
Entrez ID		114548
HPRD ID		05915
Ensembl ID		ENSG00000162711
Uniprot IDs		B2RC97 Q96P20
PDB IDs		3QF2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Negative Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-1 Beta Production Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Negative Regulation Of Signal Transduction Positive Regulation Of Peptidase Activity Negative Regulation Of Signaling Positive Regulation Of Protein Complex Assembly Positive Regulation Of Protein Secretion Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Apoptotic Process Regulation Of Cell Death Protein Processing Regulation Of Intracellular Signal Transduction Positive Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Secretion Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Transport
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