NLRP3 and FAF1

Number of citations of the paper that reports this interaction (PMID 17046979)
7

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NLRP3	FAF1
Gene Name		NLR family, pyrin domain containing 3	Fas (TNFRSF6) associated factor 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol NLRP3 Inflammasome Complex	Nucleus Nuclear Envelope Cytosol CD95 Death-inducing Signaling Complex Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Binding Peptidoglycan Binding	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Negative Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1 Beta Production Interleukin-18 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Interleukin-1 Secretion Negative Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Defense Response To Virus Cellular Response To Lipopolysaccharide	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS		C-reactive protein ( 21300955) Fibrinogen ( 20031576) Word reading ( 23738518)	Depression and alcohol dependence ( 22064162) Ventricular conduction ( 21076409)
Protein-Protein Interactions		3 interactors: CARD8 FAF1 PYCARD	37 interactors: ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 TAF1D TK1 TNNT1 TSC22D1 UROD VAPB
Entrez ID		114548	11124
HPRD ID		05915	05124
Ensembl ID		ENSG00000162711	ENSG00000185104
Uniprot IDs		B2RC97 Q96P20	B4DEJ6 Q9UNN5
PDB IDs		3QF2	1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?		Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Negative Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-1 Beta Production Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Negative Regulation Of Signal Transduction Positive Regulation Of Peptidase Activity Negative Regulation Of Signaling Positive Regulation Of Protein Complex Assembly Positive Regulation Of Protein Secretion Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Apoptotic Process Regulation Of Cell Death Protein Processing Regulation Of Intracellular Signal Transduction Positive Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Secretion Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Transport	Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Cyclic Compound Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Response To Lipid Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Steroid Hormone Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Establishment Of Protein Localization Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Endopeptidase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Peptidase Activity Response To External Stimulus Regulation Of Protein Localization Regulation Of Cellular Localization Leukocyte Homeostasis Regulation Of Immune System Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Kinase Activity Cell Communication Intracellular Receptor Signaling Pathway
Tagcloud ?		allergy alleviation arthropathy aseptic boy cerebrospinal china corticosteroid fever fundus hearing joints leucocytosis meningitis multisystem nomid normalization november peking persistently phe568lle pubmed rash searching statue summarized t1702t urticaria ventriculomegaly	agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual
Tagcloud (Difference) ?		allergy alleviation arthropathy aseptic boy cerebrospinal china corticosteroid fever fundus hearing joints leucocytosis meningitis multisystem nomid normalization november peking persistently phe568lle pubmed rash searching statue summarized t1702t urticaria ventriculomegaly	agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual
Tagcloud (Intersection) ?