NLRP3 and CD82

Number of citations of the paper that reports this interaction (PubMedID 36600050)
68

Data Source:
BioGRID (affinity chromatography technology, pull down, unspecified method)

		NLRP3	CD82
Description		NLR family pyrin domain containing 3	CD82 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Membrane Interphase Microtubule Organizing Center Canonical Inflammasome Complex NLRP3 Inflammasome Complex	Plasma Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding Peptidoglycan Binding ADP Binding Sequence-specific DNA Binding Molecular Adaptor Activity Phosphatidylinositol-4-phosphate Binding DNA-binding Transcription Factor Binding Molecular Sensor Activity Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity Phosphatidylinositol Phosphate Binding	Protein Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Immune System Process Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Regulation Of DNA-templated Transcription Apoptotic Process Defense Response Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Detection Of Biotic Stimulus Response To Virus Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-4 Production Interleukin-18-mediated Signaling Pathway NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Protein Maturation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Virus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Cytoprotection by HMOX1
Drugs
Diseases		Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) C-reactive protein levels ( 21300955 30388399) Fibrinogen ( 23969696 20031576) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252 32888494) Word reading ( 23738518)	Blond vs. brown/black hair color ( 30531825) Cadmium levels ( 26025379) Hemostatic factors and hematological phenotypes ( 22443383) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Lymphocyte count ( 32888494) Male-pattern baldness ( 27182965) Mean reticulocyte volume ( 32888494) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) TNF-alpha gene expression levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683)
Interacting Genes		15 interacting genes: ANAPC10 ATP1B3 CARD8 CD82 CSNK1A1 CUL1 FAF1 FBXL2 HERC5 IRGM LAMTOR1 MARCHF7 MARK4 PGM1 PYCARD	29 interacting genes: BDKRB2 BRCC3 CANX CD19 CD4 CD63 CHRM5 CREB3 EGFR ERBB2 ERBB3 FFAR2 HBEGF HLA-DMA HLA-DMB HLA-DRA IGSF8 ITGA3 ITGA4 ITGA6 ITGB1 ITGB2 KLRC1 LRP1 NLRP3 NUP88 PTGFRN SMIM3 VANGL1
Entrez ID		114548	3732
HPRD ID		05915	09004
Ensembl ID		ENSG00000162711	ENSG00000085117
Uniprot IDs		A0A7I2PJH0 A0A7I2PMC6 A0A7I2PRX0 A0A7I2R3P8 Q96P20	P27701
PDB IDs		2NAQ 3QF2 6NPY 7ALV 7PZC 7PZD 7VTP 7ZGU 8EJ4 8ERT 8ETR 8RI2 8SWF 8SWK 8SXN 8WSM 8ZEM 9DH3 9GU4 9MGY 9MIE 9MIG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Autophagy NLRP3 Inflammasome Complex Assembly Regulation Of Protein-containing Complex Assembly Autophagosome Assembly Autophagosome Organization Negative Regulation Of Intracellular Signal Transduction Protein Metabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Protein Catabolic Process Regulation Of Intracellular Signal Transduction Vacuole Organization Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Response To Virus SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process TORC1 Signaling Lysosome Organization NLRP3 Inflammasome Complex Regulation Of Defense Response To Virus Proteolysis Cysteine-type Endopeptidase Activator Activity Proteasomal Protein Catabolic Process Intracellular Signal Transduction Post-translational Protein Modification TOR Signaling Canonical Inflammasome Complex CARD Domain Binding Catabolic Process Regulation Of TORC1 Signaling Negative Regulation Of Signal Transduction Defense Response To Virus Ubiquitin Binding Negative Regulation Of Autophagy Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity Innate Immune Response Protein Modification By Small Protein Conjugation	Cell Surface Receptor Complex Integrin Complex Cell Surface Receptor Signaling Pathway Membrane Positive Regulation Of Cell Adhesion Regulation Of Multicellular Organismal Process Signaling Receptor Activity Cell-matrix Adhesion Regulation Of Cell Adhesion ERBB2 Signaling Pathway Immune System Process MHC Class II Protein Complex Binding Regulation Of Leukocyte Cell-cell Adhesion Cell-substrate Adhesion ERBB2-EGFR Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Signal Transduction Positive Regulation Of Immune Response Positive Regulation Of Cell-cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Plasma Membrane Peptide Antigen Assembly With MHC Class II Protein Complex Regulation Of Cell Migration ERBB3:ERBB2 Complex MHC Class II Protein Complex Integrin Alpha6-beta1 Complex Integrin Alpha3-beta1 Complex Coreceptor Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Regulation Of Immune System Process Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Immune Effector Process Focal Adhesion Clathrin-coated Endocytic Vesicle Membrane Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation Integrin Alpha4-beta1 Complex ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery
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