NLRP3 and CARD8

Number of citations of the paper that reports this interaction (PMID 15030775)
246

Data Source:
HPRD (in vivo)

		NLRP3	CARD8
Gene Name		NLR family, pyrin domain containing 3	caspase recruitment domain family, member 8
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol NLRP3 Inflammasome Complex	Nucleus Nucleoplasm Cytoplasm NLRP3 Inflammasome Complex
	Molecular Function	Protein Binding ATP Binding Peptidoglycan Binding	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Acute Inflammatory Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Negative Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1 Beta Production Interleukin-18 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Interleukin-1 Secretion Negative Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Defense Response To Virus Cellular Response To Lipopolysaccharide	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS		C-reactive protein ( 21300955) Fibrinogen ( 20031576) Word reading ( 23738518)
Protein-Protein Interactions		3 interactors: CARD8 FAF1 PYCARD	8 interactors: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG NLRP2 NLRP3
Entrez ID		114548	22900
HPRD ID		05915	16425
Ensembl ID		ENSG00000162711	ENSG00000105483
Uniprot IDs		B2RC97 Q96P20	E5RFV9 I6L9C6 Q9Y2G2
PDB IDs		3QF2	4IKM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Negative Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-1 Beta Production Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Negative Regulation Of Signal Transduction Positive Regulation Of Peptidase Activity Negative Regulation Of Signaling Positive Regulation Of Protein Complex Assembly Positive Regulation Of Protein Secretion Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Apoptotic Process Regulation Of Cell Death Protein Processing Regulation Of Intracellular Signal Transduction Positive Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Secretion Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Transport	Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Peptidase Activity Positive Regulation Of Interleukin-1 Production Regulation Of Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Metabolic Process Regulation Of Interleukin-1 Beta Production Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cytokine Production Zymogen Activation Apoptotic Process Programmed Cell Death Interleukin-1 Beta Production Cell Death Death Regulation Of Cytokine Secretion Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Protein Secretion Positive Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Other Organism Positive Regulation Of Catalytic Activity Protein Processing Response To Biotic Stimulus Innate Immune Response Regulation Of Metabolic Process
Tagcloud ?		allergy alleviation arthropathy aseptic boy cerebrospinal china corticosteroid fever fundus hearing joints leucocytosis meningitis multisystem nomid normalization november peking persistently phe568lle pubmed rash searching statue summarized t1702t urticaria ventriculomegaly	ancient archaea autoproteolysis autoproteolytic deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5
Tagcloud (Difference) ?		allergy alleviation arthropathy aseptic boy cerebrospinal china corticosteroid fever fundus hearing joints leucocytosis meningitis multisystem nomid normalization november peking persistently phe568lle pubmed rash searching statue summarized t1702t urticaria ventriculomegaly	ancient archaea autoproteolysis autoproteolytic deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5
Tagcloud (Intersection) ?