NLRP3 and MARK4

Number of citations of the paper that reports this interaction (PubMedID 28656979)
50

Data Source:
BioGRID (pull down)

		NLRP3	MARK4
Description		NLR family pyrin domain containing 3	microtubule affinity regulating kinase 4
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Membrane Interphase Microtubule Organizing Center Canonical Inflammasome Complex NLRP3 Inflammasome Complex	Gamma-tubulin Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cytoskeleton Dendrite Midbody Ciliary Basal Body Cell Projection Neuron Projection
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding Peptidoglycan Binding ADP Binding Sequence-specific DNA Binding Molecular Adaptor Activity Phosphatidylinositol-4-phosphate Binding DNA-binding Transcription Factor Binding Molecular Sensor Activity Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity Phosphatidylinositol Phosphate Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Anchor Activity Kinase Activity Transferase Activity Gamma-tubulin Binding Ubiquitin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Pattern Recognition Receptor Signaling Pathway Immune System Process Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Regulation Of DNA-templated Transcription Apoptotic Process Defense Response Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Detection Of Biotic Stimulus Response To Virus Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-4 Production Interleukin-18-mediated Signaling Pathway NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Protein Maturation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Virus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 2 Cell Cytokine Production	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Nervous System Development Cell Projection Organization Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Cilium Organization Positive Regulation Of Cilium Assembly Positive Regulation Of Cell Cycle Regulation Of Centrosome Cycle Microtubule Polymerization Cell Division Cilium Disassembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Centrosome
Pathways		Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Cytoprotection by HMOX1	Anchoring of the basal body to the plasma membrane
Drugs			Fostamatinib
Diseases		Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) C-reactive protein levels ( 21300955 30388399) Fibrinogen ( 23969696 20031576) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252 32888494) Word reading ( 23738518)	Adult body size ( 32376654) Advanced age-related macular degeneration ( 26691988) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Granulocyte count ( 27863252) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) LDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental longevity (father's attained age) ( 29227965) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32203549) White blood cell count ( 27863252 32888494)
Interacting Genes		15 interacting genes: ANAPC10 ATP1B3 CARD8 CD82 CSNK1A1 CUL1 FAF1 FBXL2 HERC5 IRGM LAMTOR1 MARCHF7 MARK4 PGM1 PYCARD	32 interacting genes: AKT1 APLNR CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MED20 MTUS2 NEDD4 NLRP3 NOTCH2NLA ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP PTBP1 RPTOR STK11 TUBA4A TUBB TUBG1 YWHAB YWHAH YWHAZ
Entrez ID		114548	57787
HPRD ID		05915	09402
Ensembl ID		ENSG00000162711	ENSG00000007047
Uniprot IDs		A0A7I2PJH0 A0A7I2PMC6 A0A7I2PRX0 A0A7I2R3P8 Q96P20	Q96L34
PDB IDs		2NAQ 3QF2 6NPY 7ALV 7PZC 7PZD 7VTP 7ZGU 8EJ4 8ERT 8ETR 8RI2 8SWF 8SWK 8SXN 8WSM 8ZEM 9DH3 9GU4 9MGY 9MIE 9MIG	5ES1 8XFL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Autophagy NLRP3 Inflammasome Complex Assembly Regulation Of Protein-containing Complex Assembly Autophagosome Assembly Autophagosome Organization Negative Regulation Of Intracellular Signal Transduction Protein Metabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Protein Catabolic Process Regulation Of Intracellular Signal Transduction Vacuole Organization Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Response To Virus SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process TORC1 Signaling Lysosome Organization NLRP3 Inflammasome Complex Regulation Of Defense Response To Virus Proteolysis Cysteine-type Endopeptidase Activator Activity Proteasomal Protein Catabolic Process Intracellular Signal Transduction Post-translational Protein Modification TOR Signaling Canonical Inflammasome Complex CARD Domain Binding Catabolic Process Regulation Of TORC1 Signaling Negative Regulation Of Signal Transduction Defense Response To Virus Ubiquitin Binding Negative Regulation Of Autophagy Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity Innate Immune Response Protein Modification By Small Protein Conjugation	Microtubule Cytoskeleton Protein Domain Specific Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Phosphoserine Residue Binding Microtubule Regulation Of Cellular Component Organization Cytosol Cytoskeleton Structural Molecule Activity Regulation Of Transport Golgi Localization Organelle Organization Cytoplasm Regulation Of Cellular Localization Tubulin Binding Regulation Of Cell Communication Regulation Of Signaling Cilium Intracellular Protein Localization GTP-dependent Protein Binding Cytoskeleton Organization Extracellular Exosome Regulation Of Neuron Projection Development Positive Regulation Of Transport Regulation Of Synapse Organization Negative Regulation Of Cell Projection Organization Positive Regulation Of Vesicle Transport Along Microtubule Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Supramolecular Fiber Organization Regulation Of Signal Transduction Regulation Of Protein Localization Regulation Of TORC1 Signaling Neuron Projection Main Axon Nuclear Receptor-mediated Corticosteroid Signaling Pathway Structural Constituent Of Cytoskeleton Protein Targeting PAR Polarity Complex Enzyme Binding Regulation Of Cell Growth Microtubule-based Process Establishment Of Golgi Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Microtubule Binding Regulation Of Cell Development Regulation Of Organelle Transport Along Microtubule Transmembrane Transporter Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Nervous System Development
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