NLRP3 and ATP1B3

Number of citations of the paper that reports this interaction (PubMedID 30653357)
0

Data Source:
BioGRID (two hybrid)

		NLRP3	ATP1B3
Description		NLR family pyrin domain containing 3	ATPase Na+/K+ transporting subunit beta 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Membrane Interphase Microtubule Organizing Center Canonical Inflammasome Complex NLRP3 Inflammasome Complex	Cytoplasm Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Sperm Flagellum Melanosome Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding Peptidoglycan Binding ADP Binding Sequence-specific DNA Binding Molecular Adaptor Activity Phosphatidylinositol-4-phosphate Binding DNA-binding Transcription Factor Binding Molecular Sensor Activity Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity Phosphatidylinositol Phosphate Binding	ATPase Activator Activity Protein Binding Protein-macromolecule Adaptor Activity ATPase Binding Transporter Activator Activity
	Biological Process	Pattern Recognition Receptor Signaling Pathway Immune System Process Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Regulation Of DNA-templated Transcription Apoptotic Process Defense Response Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Detection Of Biotic Stimulus Response To Virus Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-4 Production Interleukin-18-mediated Signaling Pathway NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Protein Maturation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Virus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 2 Cell Cytokine Production	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Intracellular Potassium Ion Homeostasis Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Stabilization Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Repolarization Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Cytoprotection by HMOX1	Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Bisacodyl Tegoprazan
Diseases		Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) C-reactive protein levels ( 21300955 30388399) Fibrinogen ( 23969696 20031576) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252 32888494) Word reading ( 23738518)	Blond vs. brown/black hair color ( 30531825) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulse pressure ( 27841878) Red cell distribution width ( 27863252 28957414 32888494) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 26503584) Total hippocampal volume ( 30279459) Waist-hip ratio ( 28552196) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: ANAPC10 ATP1B3 CARD8 CD82 CSNK1A1 CUL1 FAF1 FBXL2 HERC5 IRGM LAMTOR1 MARCHF7 MARK4 PGM1 PYCARD	14 interacting genes: BAALC BARD1 BRCA1 CTXN3 NLRP3 OGT PAXIP1 PEA15 SMAGP STOM TMEM98 TRIM14 UPF2 USP4
Entrez ID		114548	483
HPRD ID		05915	03521
Ensembl ID		ENSG00000162711	ENSG00000069849
Uniprot IDs		A0A7I2PJH0 A0A7I2PMC6 A0A7I2PRX0 A0A7I2R3P8 Q96P20	P54709
PDB IDs		2NAQ 3QF2 6NPY 7ALV 7PZC 7PZD 7VTP 7ZGU 8EJ4 8ERT 8ETR 8RI2 8SWF 8SWK 8SXN 8WSM 8ZEM 9DH3 9GU4 9MGY 9MIE 9MIG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Autophagy NLRP3 Inflammasome Complex Assembly Regulation Of Protein-containing Complex Assembly Autophagosome Assembly Autophagosome Organization Negative Regulation Of Intracellular Signal Transduction Protein Metabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Protein Catabolic Process Regulation Of Intracellular Signal Transduction Vacuole Organization Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Response To Virus SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process TORC1 Signaling Lysosome Organization NLRP3 Inflammasome Complex Regulation Of Defense Response To Virus Proteolysis Cysteine-type Endopeptidase Activator Activity Proteasomal Protein Catabolic Process Intracellular Signal Transduction Post-translational Protein Modification TOR Signaling Canonical Inflammasome Complex CARD Domain Binding Catabolic Process Regulation Of TORC1 Signaling Negative Regulation Of Signal Transduction Defense Response To Virus Ubiquitin Binding Negative Regulation Of Autophagy Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity Innate Immune Response Protein Modification By Small Protein Conjugation	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification DNA Strand Resection Involved In Replication Fork Processing RNA Polymerase Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Ubiquitin Protein Ligase Activity Response To Ionizing Radiation Negative Regulation Of Gene Expression Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Homologous Recombination Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Pyroptotic Inflammatory Response Regulation Of Protein Localization Negative Regulation Of MRNA 3'-end Processing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Adenosine Receptor Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Mitotic G2/M Transition Checkpoint Negative Regulation Of Metabolic Process DNA Recombination Regulation Of Protein Metabolic Process TORC1 Signaling Negative Regulation Of Protein Metabolic Process Positive Regulation Of TORC1 Signaling Circadian Regulation Of Gene Expression Protein Modification Process Protein Polyubiquitination Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Regulation Of Protein Modification Process Negative Regulation Of Protein Ubiquitination Regulation Of Macromolecule Biosynthetic Process
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