PDLIM1 and PGS1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PDLIM1	PGS1
Description		PDZ and LIM domain 1	phosphatidylglycerophosphate synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Transcription Regulator Complex Cytoplasm Cytoskeleton Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum
	Molecular Function	Transcription Coactivator Activity Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion	Nucleotide Binding Catalytic Activity Calcium Ion Binding ATP Binding CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Activity Transferase Activity
	Biological Process	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Heart Development Fibroblast Migration Maintenance Of Cell Polarity Actin Cytoskeleton Organization Establishment Or Maintenance Of Actin Cytoskeleton Polarity Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Muscle Structure Development Cell-cell Adhesion	Lipid Metabolic Process Phosphatidylglycerol Biosynthetic Process Phospholipid Biosynthetic Process Cardiolipin Biosynthetic Process Diacylglycerol Metabolic Process
Pathways			Synthesis of PG
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Mean platelet volume ( 27863252 32888494) Suicide risk ( 21041247) White blood cell count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) HDL cholesterol ( 24097068 25961943 30275531 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494 27863252) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Systemic lupus erythematosus ( 33272962) Total cholesterol levels ( 30275531) Triglyceride levels ( 32203549 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531)
Interacting Genes		16 interacting genes: ACTN1 ACTN2 ACTN4 AGK GABARAPL2 GFAP MAP1LC3C MAPK6 PGS1 PITX2 PTGER4 RLIM RPS6KA5 STK35 SUPT4H1 VIM	2 interacting genes: GABARAP PDLIM1
Entrez ID		9124	9489
HPRD ID		09326	17841
Ensembl ID		ENSG00000107438	ENSG00000087157
Uniprot IDs		O00151 V9HW92	Q32NB8
PDB IDs		1X62 2PKT
Enriched GO Terms of Interacting Partners?		Pseudopodium Muscle Cell Development Integrin Binding Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Cortical Actin Cytoskeleton Bergmann Glial Cell Differentiation Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Cell Development Astrocyte Development Z Disc Transmembrane Transporter Binding Focal Adhesion Assembly Astrocyte Differentiation Organelle Organization Actin Filament Binding Positive Regulation Of Ion Transmembrane Transporter Activity Focal Adhesion Cell Junction Positive Regulation Of Transporter Activity Positive Regulation Of Macromolecule Biosynthetic Process Cell-substrate Junction Organization Cell-substrate Junction Assembly Cardiac Cell Development Actin Filament Uncapping Cardiac Muscle Cell Development Intermediate Filament Cytoskeleton Superior Vena Cava Morphogenesis Subthalamic Nucleus Development Negative Regulation Of Eosinophil Extravasation Histone H2AS1 Kinase Activity CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Activity Autophagosome Maturation Acylglycerol Kinase Activity Autophagosome Membrane Sarcomere Mitophagy Positive Regulation Of Biosynthetic Process Cytoskeleton Organization Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Postsynapse Titin Z Domain Binding Glial Cell Development Left Lung Morphogenesis Prolactin Secreting Cell Differentiation Cell Proliferation Involved In Outflow Tract Morphogenesis Pulmonary Vein Morphogenesis Septin Cytoskeleton	Muscle Alpha-actinin Binding Establishment Or Maintenance Of Actin Cytoskeleton Polarity Maintenance Of Cell Polarity Cadherin Binding Involved In Cell-cell Adhesion Actin Cytoskeleton Fibroblast Migration Regulation Of Protein K48-linked Ubiquitination Phosphatidylethanolamine Binding GABA Receptor Binding Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Smooth Endoplasmic Reticulum Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Cellular Response To Nitrogen Starvation Filamentous Actin Cytoskeleton Organization Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Protein Polyubiquitination Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Rac Protein Signal Transduction Microtubule Associated Complex Beta-tubulin Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Autophagosome Maturation Sperm Midpiece Autophagosome Membrane Mitophagy Cytoskeleton Actin Filament Bundle Assembly Actin Filament Bundle Organization Autophagy Of Mitochondrion
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