PDLIM1 and AGK

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PDLIM1	AGK
Description		PDZ and LIM domain 1	acylglycerol kinase
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GO Annotations	Cellular Component	Stress Fiber Transcription Regulator Complex Cytoplasm Cytoskeleton Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Membrane Mitochondrial Membrane TIM22 Mitochondrial Import Inner Membrane Insertion Complex
	Molecular Function	Transcription Coactivator Activity Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion	Nucleotide Binding Lipid Kinase Activity Ceramide Kinase Activity ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Sphingosine Kinase Activity Kinase Activity Transferase Activity Acylglycerol Kinase Activity
	Biological Process	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Heart Development Fibroblast Migration Maintenance Of Cell Polarity Actin Cytoskeleton Organization Establishment Or Maintenance Of Actin Cytoskeleton Polarity Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Muscle Structure Development Cell-cell Adhesion	Lipid Metabolic Process Protein Insertion Into Mitochondrial Inner Membrane Glycerolipid Metabolic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Lipid Phosphorylation
Pathways			Glycerophospholipid biosynthesis Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Mean platelet volume ( 27863252 32888494) Suicide risk ( 21041247) White blood cell count ( 32888494)	Mood disorder and prion disease ( 25897833) Psoriasis ( 31376382)
Interacting Genes		16 interacting genes: ACTN1 ACTN2 ACTN4 AGK GABARAPL2 GFAP MAP1LC3C MAPK6 PGS1 PITX2 PTGER4 RLIM RPS6KA5 STK35 SUPT4H1 VIM	3 interacting genes: HCK PDLIM1 SNX4
Entrez ID		9124	55750
HPRD ID		09326	08554
Ensembl ID		ENSG00000107438	ENSG00000006530
Uniprot IDs		O00151 V9HW92	A0A3B3ISZ0 A4D1U5 Q53H12
PDB IDs		1X62 2PKT	7CGP
Enriched GO Terms of Interacting Partners?		Pseudopodium Muscle Cell Development Integrin Binding Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Cortical Actin Cytoskeleton Bergmann Glial Cell Differentiation Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Cell Development Astrocyte Development Z Disc Transmembrane Transporter Binding Focal Adhesion Assembly Astrocyte Differentiation Organelle Organization Actin Filament Binding Positive Regulation Of Ion Transmembrane Transporter Activity Focal Adhesion Cell Junction Positive Regulation Of Transporter Activity Positive Regulation Of Macromolecule Biosynthetic Process Cell-substrate Junction Organization Cell-substrate Junction Assembly Cardiac Cell Development Actin Filament Uncapping Cardiac Muscle Cell Development Intermediate Filament Cytoskeleton Superior Vena Cava Morphogenesis Subthalamic Nucleus Development Negative Regulation Of Eosinophil Extravasation Histone H2AS1 Kinase Activity CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Activity Autophagosome Maturation Acylglycerol Kinase Activity Autophagosome Membrane Sarcomere Mitophagy Positive Regulation Of Biosynthetic Process Cytoskeleton Organization Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Postsynapse Titin Z Domain Binding Glial Cell Development Left Lung Morphogenesis Prolactin Secreting Cell Differentiation Cell Proliferation Involved In Outflow Tract Morphogenesis Pulmonary Vein Morphogenesis Septin Cytoskeleton	Respiratory Burst After Phagocytosis Leukocyte Migration Involved In Immune Response Regulation Of Organelle Assembly Leptin Receptor Binding Positive Regulation Of Histamine Secretion By Mast Cell Establishment Or Maintenance Of Actin Cytoskeleton Polarity Type II Interferon-mediated Signaling Pathway Regulation Of Podosome Assembly Positive Regulation Of Cellular Component Biogenesis Lipid Binding Respiratory Burst Involved In Defense Response Focal Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Respiratory Burst Regulation Of Inflammatory Response Positive Regulation Of Organelle Organization Positive Regulation Of Defense Response Regulation Of Vesicle-mediated Transport Cytoplasmic Dynein Complex Regulation Of Histamine Secretion By Mast Cell Positive Regulation Of Autophagosome Assembly Transferrin Receptor Binding Insulin Receptor Binding Positive Regulation Of Mast Cell Degranulation Presynaptic Endosome Muscle Alpha-actinin Binding Maintenance Of Cell Polarity Cadherin Binding Involved In Cell-cell Adhesion Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Fibroblast Migration Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Vacuole Organization Filamentous Actin Regulation Of Mast Cell Degranulation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Phosphotyrosine Residue Binding Regulation Of Defense Response Cell Adhesion Cell Migration Leukocyte Degranulation Positive Regulation Of Actin Filament Polymerization Non-membrane Spanning Protein Tyrosine Kinase Activity Lipopolysaccharide-mediated Signaling Pathway SNARE Complex Positive Regulation Of Regulated Secretory Pathway Regulation Of Autophagosome Assembly Phosphatidylinositol-3-phosphate Binding
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