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PDLIM1 and RPS6KA5
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
PDLIM1
RPS6KA5
Gene Name
PDZ and LIM domain 1
ribosomal protein S6 kinase, 90kDa, polypeptide 5
Image
Gene Ontology Annotations
Cellular Component
Transcription Factor Complex
Cytoplasm
Cytoskeleton
Focal Adhesion
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Transcription Coactivator Activity
Zinc Ion Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Response To Hypoxia
Regulation Of Transcription, DNA-templated
Response To Oxidative Stress
Negative Regulation Of Cytokine Production
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Inflammatory Response
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Histone Phosphorylation
Positive Regulation Of CREB Transcription Factor Activity
Positive Regulation Of Histone Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Histone H3-S10 Phosphorylation
Histone H3-S28 Phosphorylation
Histone H2A-S1 Phosphorylation
Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Pathways
CREB phosphorylation
Axon guidance
Toll Like Receptor 7/8 (TLR7/8) Cascade
CREB phosphorylation
L1CAM interactions
Recycling pathway of L1
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
NCAM signaling for neurite out-growth
Toll Like Receptor 9 (TLR9) Cascade
ERK/MAPK targets
Innate Immune System
Signalling by NGF
MAP kinase activation in TLR cascade
TRIF-mediated TLR3/TLR4 signaling
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
ERK/MAPK targets
Toll Like Receptor 3 (TLR3) Cascade
MAPK targets/ Nuclear events mediated by MAP kinases
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Bone mineral density (
22504420
)
Protein-Protein Interactions
13 interactors:
ACTN1
ACTN2
ACTN4
AGK
GFAP
MAPK6
PGS1
PITX2
RLIM
RPS6KA5
STK35
SUPT4H1
VIM
59 interactors:
ACTG1
AKT1S1
ALG8
APP
ATF1
ATF2
BAD
CEBPB
CREB1
CREBBP
CRMP1
CSNK2B
DDAH2
DNAJC11
EIF4E
EIF4EBP1
EP300
ERH
ETV1
EZH2
FN1
GPRASP2
HIST1H1B
HIST1H3E
HIST2H2BE
HIST2H3C
HIST2H4A
HIST3H2A
HIST3H2BB
HIST3H3
HIST4H4
HMGN1
HSPB1
HSPB2
IL17RB
ITSN1
MAPK11
MAPK14
MAPT
MBP
MDFIC
NR4A1
PDLIM1
PLA2G4A
RAI1
RELA
RNF19A
ROBO2
RPA1
SMAD6
SMARCB1
STAT1
STAT3
STK11
TH
TXNDC11
UNC119
ZAK
ZNF775
Entrez ID
9124
9252
HPRD ID
09326
06789
Ensembl ID
ENSG00000107438
ENSG00000100784
Uniprot IDs
O00151
B7Z2Y5
O75582
Q9UG98
PDB IDs
1X62
2PKT
1VZO
3KN5
3KN6
Enriched GO Terms of Interacting Partners
?
Protein Localization To Tight Junction
Bergmann Glial Cell Differentiation
Protein Localization To Cell Junction
Platelet Degranulation
Intermediate Filament Organization
Actin Crosslink Formation
Astrocyte Development
Actin-myosin Filament Sliding
Focal Adhesion Assembly
Muscle Filament Sliding
Platelet Activation
Cell Junction Assembly
Cell-cell Junction Organization
Intermediate Filament Cytoskeleton Organization
Astrocyte Differentiation
Intermediate Filament-based Process
Actin-mediated Cell Contraction
Tight Junction Assembly
Adherens Junction Assembly
Actin Filament-based Process
Positive Regulation Of Ion Transmembrane Transporter Activity
Cell-substrate Junction Assembly
Response To Wounding
Positive Regulation Of Transporter Activity
Actin Filament Bundle Assembly
Actin Filament-based Movement
Histone H2A-S1 Phosphorylation
Subthalamic Nucleus Development
Prolactin Secreting Cell Differentiation
Random Inactivation Of X Chromosome
Positive Regulation Of Schwann Cell Proliferation
Superior Vena Cava Morphogenesis
Apical Junction Assembly
Exocytosis
Positive Regulation Of Ion Transmembrane Transport
Adherens Junction Organization
Cell Proliferation Involved In Outflow Tract Morphogenesis
Subthalamus Development
Left Lung Morphogenesis
Pulmonary Vein Morphogenesis
Blood Coagulation
Glial Cell Development
Hemostasis
Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Extraocular Skeletal Muscle Development
Pulmonary Myocardium Development
Positive Regulation Of Pinocytosis
Left Lung Development
Cell-cell Junction Assembly
Negative Regulation Of Neuron Projection Development
Response To Stress
Positive Regulation Of Cellular Metabolic Process
Response To Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Metabolic Process
Defense Response
Enzyme Linked Receptor Protein Signaling Pathway
Response To Abiotic Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Cellular Response To Organic Substance
Cellular Response To Stress
Neurotrophin Signaling Pathway
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Cell Differentiation
Innate Immune Response
Immune Response
Response To Organic Substance
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
System Development
Regulation Of Cell Differentiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Developmental Process
Nucleobase-containing Compound Metabolic Process
Nitrogen Compound Metabolic Process
Anatomical Structure Development
Response To Hormone
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Stimulus
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Multicellular Organismal Development
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Immune System Process
Chromatin Organization
Chromosome Organization
Generation Of Neurons
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Immune Response-regulating Signaling Pathway
Stress-activated MAPK Cascade
MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud
?
27a
5p
arrays
bioinformatics
cbl
changed
creb
creb1
directive
erk2
escc
esophageal
folds
grb2
mapk1
mapk14
microrna
mir
mirna
mirnas
ngfr
options
prediction
pt1n0
sos1
sprouty
spry2
taqman
verify
Tagcloud (Difference)
?
27a
5p
arrays
bioinformatics
cbl
changed
creb
creb1
directive
erk2
escc
esophageal
folds
grb2
mapk1
mapk14
microrna
mir
mirna
mirnas
ngfr
options
prediction
pt1n0
sos1
sprouty
spry2
taqman
verify
Tagcloud (Intersection)
?