BNIP3L and FBXL4

Number of citations of the paper that reports this interaction (PubMedID 37568009)
29

Data Source:
BioGRID (pull down)

		BNIP3L	FBXL4
Description		BCL2 interacting protein 3 like	F-box and leucine rich repeat protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Nuclear Speck	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Cytosol Membrane Nuclear Speck SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Lamin Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macroautophagy Mitochondrial Protein Catabolic Process Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Defense Response To Virus Cellular Response To Hypoxia Mitochondrial Outer Membrane Permeabilization Regulation Of Mitophagy Regulation Of Protein Targeting To Mitochondrion	Autophagy Of Mitochondrion Mitophagy Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitophagy
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Schizophrenia ( 28991256 30285260)	Chronotype ( 30696823) Depression ( 29700475) Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889)
Interacting Genes		36 interacting genes: ADIPOQ BCL2 BCL2L1 BNIP3 CAMK1D CASK CLEC7A CLN8 CYB5B DOK5 DUSP3 ECM1 EWSR1 FATE1 FBXL4 GABARAPL1 GABARAPL2 GBP2 GNB5 HTR2B KLHL23 LDLRAD1 LMNA MALL MAP1LC3A NGFR RHEB RINT1 ROBO2 SMCO4 STEAP3 TMEM11 TMEM120B TMEM132D TMPRSS4 TNMD	3 interacting genes: BNIP3 BNIP3L SKP1
Entrez ID		665	26235
HPRD ID		07288	05738
Ensembl ID		ENSG00000104765	ENSG00000112234
Uniprot IDs		O60238 Q6IBV1	Q9UKA2
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitophagy Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Membrane Neuron Apoptotic Process Mitochondrial Membrane Organization Phosphatidylethanolamine Binding Mitochondrial Outer Membrane Dendritic Cell Apoptotic Process Macroautophagy Ubiquitin Protein Ligase Binding Autophagy Vacuole Organization Autophagosome Assembly Response To Nutrient Levels BH3 Domain Binding Autophagosome Organization Negative Regulation Of Autophagy Regulation Of Release Of Cytochrome C From Mitochondria Response To Oxidative Stress Protein Binding Regulation Of Autophagy Positive Regulation Of Cell Maturation Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Respiratory Burst Autophagosome Maturation Mitochondrion Organization Cellular Response To Nutrient Levels Identical Protein Binding Autophagosome Membrane Cellular Response To Decreased Oxygen Levels Endoplasmic Reticulum Regulation Of Mitochondrial Membrane Permeability Response To Oxygen-glucose Deprivation Regulation Of Endothelial Cell Proliferation Nuclear Lamina Regulation Of Locomotion Cellular Response To Oxygen Levels Negative Regulation Of Apoptotic Process Chemical Homeostasis Response To Stress Apoptotic Mitochondrial Changes Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Apoptotic Process Response To Decreased Oxygen Levels Negative Regulation Of Programmed Cell Death GABA Receptor Binding	Cellular Response To Decreased Oxygen Levels Mitochondrial Protein Catabolic Process Positive Regulation Of Macroautophagy Cellular Response To Hypoxia Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Permeabilization Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Cellular Response To Oxygen Levels Positive Regulation Of Autophagy Protein Catabolic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Macroautophagy Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Apoptotic Process Response To Hypoxia Cell Death Response To Decreased Oxygen Levels Programmed Cell Death Regulation Of Autophagy Of Mitochondrion Response To Oxygen Levels Regulation Of Mitochondrial Membrane Permeability Macromolecule Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Mitochondrion Autophagosome Adaptor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Catabolic Process Mitochondrial Membrane Organization Protein Metabolic Process Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia F-box Domain Binding I-kappaB Phosphorylation Linear Polyubiquitin Binding Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Cul7-RING Ubiquitin Ligase Complex Autophagic Cell Death Glycoprotein Ib-IX-V Complex Thrombin-activated Receptor Activity Catabolic Process Mitochondrial Outer Membrane
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