BNIP3L and DOK5

Number of citations: 0 (PubMedID 16189514)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		BNIP3L	DOK5
Name		BCL2 interacting protein 3 like	docking protein 5
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Nuclear Speck	Cytoplasm Cytosol
	Molecular Function	Protein Binding Lamin Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macroautophagy Mitochondrial Protein Catabolic Process Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Defense Response To Virus Cellular Response To Hypoxia Mitochondrial Outer Membrane Permeabilization Regulation Of Mitophagy Regulation Of Protein Targeting To Mitochondrion	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Differentiation Positive Regulation Of MAPK Cascade Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	RET signaling
GWAS		Brain morphology (MOSTest) ( 32665545 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 27863252 32888494 ) Schizophrenia ( 28991256 30285260 )	Celiac disease ( 23936387 ) Erectile dysfunction ( 30583798 ) Functional MRI ( 20215924 ) HDL cholesterol levels in HIV infection ( 33109212 )
Novel Interactors		1 novel interactors: KEAP1	None recorded
Interacting Genes		36 interacting genes: ADIPOQ BCL2 BCL2L1 BNIP3 CAMK1D CASK CLEC7A CLN8 CYB5B DOK5 DUSP3 ECM1 EWSR1 FATE1 FBXL4 GABARAPL1 GABARAPL2 GBP2 GNB5 HTR2B KLHL23 LDLRAD1 LMNA MALL MAP1LC3A NGFR RHEB RINT1 ROBO2 SMCO4 STEAP3 TMEM11 TMEM120B TMEM132D TMPRSS4 TNMD	20 interacting genes: AHDC1 ATF3 BNIP3L CCDC85B CDCA4 DOK3 EGFR FANCG IGF1R INSR NTRK2 NTRK3 OLIG1 OPRM1 PFDN5 RAI2 RET SCOC TSC1 WIZ
Entrez ID		665	55816
HPRD ID		07288	16317
Ensembl ID		ENSG00000104765	ENSG00000101134
Uniprot IDs		O60238 Q6IBV1	Q9P104
PDB IDs		Not available	1J0W
GO Terms Enriched among Interactors		Mitophagy Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Membrane Neuron Apoptotic Process Mitochondrial Membrane Organization Phosphatidylethanolamine Binding Mitochondrial Outer Membrane Dendritic Cell Apoptotic Process Macroautophagy Ubiquitin Protein Ligase Binding Autophagy Vacuole Organization Autophagosome Assembly Response To Nutrient Levels BH3 Domain Binding Autophagosome Organization Negative Regulation Of Autophagy Regulation Of Release Of Cytochrome C From Mitochondria Response To Oxidative Stress Protein Binding Regulation Of Autophagy Positive Regulation Of Cell Maturation Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Respiratory Burst Autophagosome Maturation Mitochondrion Organization Cellular Response To Nutrient Levels Identical Protein Binding Autophagosome Membrane Cellular Response To Decreased Oxygen Levels Endoplasmic Reticulum Regulation Of Mitochondrial Membrane Permeability Response To Oxygen-glucose Deprivation Regulation Of Endothelial Cell Proliferation Nuclear Lamina Regulation Of Locomotion Cellular Response To Oxygen Levels Negative Regulation Of Apoptotic Process Chemical Homeostasis Response To Stress Apoptotic Mitochondrial Changes Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Apoptotic Process Response To Decreased Oxygen Levels Negative Regulation Of Programmed Cell Death GABA Receptor Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Insulin Receptor Activity Axon Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Complex Neurotrophin Receptor Activity Neurotrophin Binding Insulin Binding Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Kinase Activity Dendritic Spine Maintenance Action Potential Propagation Neuronal Action Potential Propagation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Insulin-like Growth Factor I Binding Insulin Receptor Substrate Binding Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Endosome Phosphatidylinositol 3-kinase Binding Myelination Axon Ensheathment Myelination In Peripheral Nervous System Learning Or Memory Positive Regulation Of Cell Junction Assembly Cellular Response To Growth Factor Stimulus Endosome Membrane Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Nervous System Process Protein Autophosphorylation Amyloid-beta Clearance Mechanoreceptor Differentiation Cognition Positive Regulation Of Cell Motility Response To Growth Factor Positive Regulation Of Cell Population Proliferation Neurotrophin Signaling Pathway Positive Regulation Of Locomotion