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TSSK1B and TGFBR2
Number of citations of the paper that reports this interaction (PMID
15761153
)
154
Data Source:
HPRD
(in vivo)
TSSK1B
TGFBR2
Gene Name
testis-specific serine kinase 1B
transforming growth factor, beta receptor II (70/80kDa)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Acrosomal Vesicle
Motile Cilium
Cytosol
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Integral Component Of Membrane
Receptor Complex
Transforming Growth Factor Beta Receptor Homodimeric Complex
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
ATP Binding
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
SMAD Binding
Metal Ion Binding
Transforming Growth Factor Beta Binding
Biological Process
Protein Phosphorylation
Multicellular Organismal Development
Spermatid Development
Blood Vessel Development
Patterning Of Blood Vessels
Vasculogenesis
In Utero Embryonic Development
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Growth Plate Cartilage Chondrocyte Growth
Protein Phosphorylation
Receptor-mediated Endocytosis
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Smoothened Signaling Pathway
Gastrulation
Brain Development
Heart Development
Embryo Implantation
Aging
Response To Nutrient
Positive Regulation Of Cell Proliferation
Response To Mechanical Stimulus
Response To Glucose
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Signal Transduction By Phosphorylation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Organ Regeneration
Activation Of Protein Kinase Activity
Embryonic Hemopoiesis
Wound Healing
Regulation Of Cell Proliferation
Response To Drug
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Skeletal Muscle Tissue Regeneration
Response To Estrogen
Positive Regulation Of Angiogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Embryonic Cranial Skeleton Morphogenesis
Positive Regulation Of NK T Cell Differentiation
Palate Development
Negative Regulation Of Cardiac Muscle Cell Proliferation
Pathway-restricted SMAD Protein Phosphorylation
Bronchus Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Response To Cholesterol
Lens Fiber Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Glycerol
Diseases
GWAS
Breast cancer (
23535729
)
Migraine (
22683712
)
Tonometry (
17903302
)
Protein-Protein Interactions
4 interactors:
CHEK2
EFS
TGFBR1
TGFBR2
44 interactors:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CBL
CCNB1
CCNB2
CD44
CDK1
CLU
CTNNB1
DAB2
DAXX
EIF3I
ENG
GOPC
KCNK18
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TCTEX1D4
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TSSK1B
ZFYVE9
Entrez ID
83942
7048
HPRD ID
11610
01823
Ensembl ID
ENSG00000212122
ENSG00000163513
Uniprot IDs
A0ZT98
Q9BXA7
A3QNQ0
D2JYI1
P37173
PDB IDs
1KTZ
1M9Z
1PLO
2PJY
3KFD
Enriched GO Terms of Interacting Partners
?
Pathway-restricted SMAD Protein Phosphorylation
Response To Cholesterol
Peptidyl-threonine Phosphorylation
Intracellular Signal Transduction
Embryonic Cranial Skeleton Morphogenesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Lens Development In Camera-type Eye
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Palate Development
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Peptidyl-serine Phosphorylation
Embryonic Skeletal System Morphogenesis
Signal Transduction Involved In Intra-S DNA Damage Checkpoint
Positive Regulation Of Tolerance Induction To Self Antigen
Transforming Growth Factor Beta Receptor Signaling Pathway
Apoptotic Process
Embryonic Skeletal System Development
Programmed Cell Death
Positive Regulation Of B Cell Tolerance Induction
Cell Death
Death
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Cellular Response To Growth Factor Stimulus
Response To Transforming Growth Factor Beta
Bronchus Morphogenesis
Positive Regulation Of Growth
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Lens Fiber Cell Apoptotic Process
Growth Plate Cartilage Chondrocyte Growth
Protein Phosphorylation
Growth Plate Cartilage Chondrocyte Development
Activation Of Protein Kinase Activity
Skeletal System Morphogenesis
Signal Transduction By Phosphorylation
Chondrocyte Hypertrophy
Positive Regulation Of Skeletal Muscle Tissue Regeneration
Growth Plate Cartilage Chondrocyte Differentiation
Common-partner SMAD Protein Phosphorylation
Positive Regulation Of NK T Cell Differentiation
Embryonic Organ Morphogenesis
Aging
Angiogenesis
Positive Regulation Of Cellular Component Movement
Parathyroid Gland Development
Camera-type Eye Development
Bronchus Development
Trachea Formation
Regulation Of Nuclear Cell Cycle DNA Replication
Eye Development
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Transforming Growth Factor Beta
Regulation Of Signal Transduction
Cellular Response To Organic Substance
Regulation Of Signaling
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Regulation Of Phosphorylation
Regulation Of Epithelial To Mesenchymal Transition
Response To Organic Substance
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Protein Phosphorylation
Positive Regulation Of Signal Transduction
Regulation Of Cellular Response To Growth Factor Stimulus
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Signal Transduction
Negative Regulation Of Signaling
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Tube Development
Response To Wounding
Regulation Of Cell Death
Signaling
Positive Regulation Of Phosphorylation
Regulation Of Cell Differentiation
Cellular Response To Stimulus
Signal Transduction
Cell Communication
Response To Stress
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Tissue Morphogenesis
Anatomical Structure Morphogenesis
Tagcloud
?
aaa
adventitial
alleles
aneurysm
aortas
aortic
betatype
disruption
elastase
elastin
fourteen
genetical
infiltration
infrarenal
medial
metalloproteinases
myhcre
peri
principal
prominently
resident
sm
smc
smooth
transforming
wise
Tagcloud (Difference)
?
aaa
adventitial
alleles
aneurysm
aortas
aortic
betatype
disruption
elastase
elastin
fourteen
genetical
infiltration
infrarenal
medial
metalloproteinases
myhcre
peri
principal
prominently
resident
sm
smc
smooth
transforming
wise
Tagcloud (Intersection)
?