TSSK1B and EFS

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TSSK1B	EFS
Description		testis specific serine kinase 1B	embryonal Fyn-associated substrate
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cilium Cytoplasmic Vesicle Motile Cilium Cell Projection	Cytoplasm Plasma Membrane Focal Adhesion
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding SH3 Domain Binding Protein Domain Specific Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Spermatid Development Cell Differentiation	Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Intracellular Signal Transduction
Pathways
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		8 interacting genes: CHEK2 EFS FAM229B FOXN1 MEOX2 TGFBR1 TGFBR2 TSKS	36 interacting genes: ABI2 AGXT APP BCAR1 BDKRB2 BLK CCDC187 CRK FYN GLMN GPANK1 LHX8 LYST MYOZ3 NCK1 NCK2 NF1 NLGN3 NPAS2 NUP155 OSTF1 PIN1 PTK2 PTK2B PTPN12 SH2D3C SH3RF2 SORBS2 SORBS3 SRC TRAPPC6A TSSK1B UBASH3B UBC YES1 ZNF417
Entrez ID		83942	10278
HPRD ID		11610	09932
Ensembl ID		ENSG00000212122	ENSG00000100842
Uniprot IDs		A0ZT98 Q9BXA7	O43281
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Ligand-receptor Complex Roof Of Mouth Development Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Blood Vessel Morphogenesis Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Binding Response To Cholesterol Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Tissue Development Lens Development In Camera-type Eye Thymus Development SMAD Binding Tube Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of SMAD Protein Signal Transduction Artery Morphogenesis Cell Proliferation Involved In Endocardial Cushion Morphogenesis Positive Regulation Of Tolerance Induction To Self Antigen Superior Endocardial Cushion Morphogenesis Inferior Endocardial Cushion Morphogenesis Cardiac Septum Morphogenesis Embryonic Skeletal System Morphogenesis Epithelial To Mesenchymal Transition Tissue Morphogenesis Regulation Of Stem Cell Proliferation Protein Serine/threonine Kinase Activity Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Hematopoietic Or Lymphoid Organ Development Bronchus Morphogenesis Transforming Growth Factor Beta Receptor Activity, Type II Positive Regulation Of B Cell Tolerance Induction Mammary Gland Morphogenesis Lymphoid Lineage Cell Migration Into Thymus Thymus Epithelium Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Proepicardium Development	Signal Complex Assembly Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Anchoring Junction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeletal Anchor Activity Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Scaffold Protein Binding Signaling Receptor Activator Activity Regulation Of Cell Adhesion ERBB Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Motility Signaling Receptor Binding Positive Regulation Of Supramolecular Fiber Organization Regulation Of Immune System Process Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Intrinsic Apoptotic Signaling Pathway Phosphotyrosine Residue Binding SH3 Domain Binding Response To Growth Factor Signal Transduction Positive Regulation Of Immune System Process Regulation Of Cell Motility Fc Receptor Signaling Pathway Regulation Of MAPK Cascade Protein Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Locomotion Immune Response-activating Signaling Pathway Leukocyte Migration Regulation Of Cell-cell Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Postsynapse Organization Positive Regulation Of Signal Transduction Negative Regulation Of Immune System Process Phosphorylation
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