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PPP2R5A and TP63
Number of citations of the paper that reports this interaction (PubMedID
12086851
)
0
Data Source:
HPRD
(in vitro)
PPP2R5A
TP63
Description
protein phosphatase 2 regulatory subunit B'alpha
tumor protein p63
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Nucleus
Chromosome
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Z Disc
M Band
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Dendrite
Protein-containing Complex
Molecular Function
Protein Binding
Kinase Inhibitor Activity
Protein Phosphatase Regulator Activity
Kinase Binding
Protein Phosphatase Activator Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
WW Domain Binding
MDM2/MDM4 Family Protein Binding
Promoter-specific Chromatin Binding
Biological Process
Signal Transduction
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Establishment Of Planar Polarity
Morphogenesis Of A Polarized Epithelium
Hair Follicle Development
Epithelial Cell Development
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Notch Signaling Pathway
Spermatogenesis
Pattern Specification Process
Ectoderm And Mesoderm Interaction
Positive Regulation Of Cell Population Proliferation
Determination Of Adult Lifespan
Epidermis Development
Animal Organ Morphogenesis
Epidermal Cell Differentiation
Proximal/distal Pattern Formation
Epidermal Cell Division
Regulation Of Epidermal Cell Division
Positive Regulation Of Keratinocyte Proliferation
Keratinocyte Differentiation
Embryonic Limb Morphogenesis
Prostate Gland Development
Epithelial Cell Differentiation
Polarized Epithelial Cell Differentiation
Hair Follicle Morphogenesis
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
Post-anal Tail Morphogenesis
Odontogenesis Of Dentin-containing Tooth
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Skin Morphogenesis
Keratinocyte Proliferation
Positive Regulation Of Cell Differentiation
Negative Regulation Of Keratinocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Sympathetic Nervous System Development
Anatomical Structure Formation Involved In Morphogenesis
Female Genitalia Morphogenesis
Stem Cell Differentiation
Protein Tetramerization
Neuron Apoptotic Process
Cloacal Septation
Prostatic Bud Formation
Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development
Establishment Of Skin Barrier
Stem Cell Proliferation
Cellular Senescence
Skin Epidermis Development
Positive Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Somatic Stem Cell Population Maintenance
Cranial Skeletal System Development
Positive Regulation Of Fibroblast Apoptotic Process
Negative Regulation Of Mesoderm Development
Positive Regulation Of Stem Cell Proliferation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
PKR-mediated signaling
Activation of PUMA and translocation to mitochondria
Pyroptosis
TP53 Regulates Metabolic Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
Split-hand/foot malformation (SHFM)
Limb-mammary syndrome
Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome)
ADULT syndrome
Ankyloblepharon-ctodermal defects-cleft lip/palate (AEC) syndrome and Rapp-Hodgkin syndrome
Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS
Deep white matter hyperintensities (
32517579
)
HDL cholesterol levels (
32203549
)
Nickel levels (
26025379
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Acute lymphoblastic leukemia (childhood) (
22076464
)
Bladder cancer (
24163127
20972438
)
Brain imaging (
20100581
)
Chlamydia trachomatis PorB antibody levels (
33204752
)
Circulating leptin levels in high cardiovascular risk (
31766143
)
Cutaneous squamous cell carcinoma (
32041948
)
EGFR mutation-positive lung adenocarcinoma (
27501781
)
Lung adenocarcinoma (
20871597
28604730
22797724
)
Lung cancer (
24880342
23143601
28604730
21725308
)
Lung cancer in never smokers (
31009812
)
Metabolite levels (
23823483
)
Non-small cell lung cancer (
31326317
)
Pancreatic cancer (
26098869
29422604
)
Postoperative stroke after cardiac surgery (
30678657
)
Psoriasis (
25903422
)
Psoriasis vulgaris (
26626624
)
Serum CC16 levels (
32839289
)
Squamous cell carcinoma (
26829030
)
Systemic lupus erythematosus (
28714469
)
Urinary bladder cancer (
20348956
18794855
)
Interacting Genes
28 interacting genes:
APC
AXIN2
BCL2
BEST1
BUB1B
CDCA2
CHEK2
CSNK1A1
CTLA4
DAPK1
DZIP1
EIF2AK2
ERICH4
GNL3
JAK2
MAPT
MOS
NEK1
NOS3
PPFIA1
PPP2R1A
PTTG1
SGO1
SHC1
SHFL
TNNT2
TP63
USHBP1
43 interacting genes:
BAG6
BTRC
CCNC
CDC20
CDKN2A
COPS6
CSNK2A1
CSNK2A2
CSNK2B
DAXX
EMX1
EP300
GCGR
GRB2
HIPK2
HNRNPAB
HP
HPX
ITIH4
KAT2B
MCRS1
MDM4
NEDD4
NIPSNAP3A
ORM1
PELI1
PELI2
PIN1
PINX1
PML
PPP1R13B
PPP2R5A
RACK1
RCHY1
SCAF4
SLC35A3
STUB1
TP53
TP73
UBASH3A
UBE2I
WT1
YAP1
Entrez ID
5525
8626
HPRD ID
03384
04469
Ensembl ID
ENSG00000066027
ENSG00000073282
Uniprot IDs
Q15172
A0A0S2Z4N5
A0A0S2Z4N6
A0A141PNN3
A0A141PNN4
B7Z8X6
C9D7D0
Q9H3D4
PDB IDs
6NTS
8SZK
1RG6
2NB1
2RMN
2Y9T
2Y9U
3QYM
3QYN
3US0
3US1
3US2
3ZY0
3ZY1
4A9Z
6FGN
6RU6
6RU7
6RU8
7Z71
7Z72
7Z73
7Z7E
8P9C
8P9D
8P9E
9GFO
Enriched GO Terms of Interacting Partners
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Cell Division
Organelle Organization
Protein Serine Kinase Activity
Protein Kinase Activity
Regulation Of Chromosome Organization
Regulation Of Cell Cycle Process
Protein Serine/threonine Kinase Activity
Kinase Activity
Beta-catenin Destruction Complex
Negative Regulation Of Osteoblast Proliferation
Protein Phosphorylation
Regulation Of Organelle Organization
Protein Autophosphorylation
Positive Regulation Of Apoptotic Process
Intracellular Signal Transduction
Positive Regulation Of Programmed Cell Death
Regulation Of Cellular Component Organization
Phosphorylation
Chromosome Segregation
Regulation Of Nuclear Division
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Process
Cytosol
Kinetochore
Chromosome, Centromeric Region
Centrosome
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Meiotic Sister Chromatid Cohesion, Centromeric
Regulation Of Osteoblast Proliferation
Regulation Of Protein Metabolic Process
Chromosome Organization
Negative Regulation Of Cell Cycle
Cytoskeleton Organization
Negative Regulation Of Cell Cycle Phase Transition
Protein Phosphatase Regulator Activity
Regulation Of Mitotic Nuclear Division
Sister Chromatid Cohesion
Regulation Of Cell Cycle Phase Transition
Cytoskeleton
Microtubule Cytoskeleton Organization
Nuclear Chromosome Segregation
Chromosome
Signal Transduction
Nucleus
Axon Development
Regulation Of Cell Communication
Cytoplasm
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Protein Metabolic Process
Negative Regulation Of Catabolic Process
Regulation Of Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Regulation Of Macromolecule Metabolic Process
Regulation Of Proteolysis
Regulation Of Primary Metabolic Process
Cellular Response To Stress
DNA Damage Response
Regulation Of Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Macromolecule Metabolic Process
Signal Transduction By P53 Class Mediator
Positive Regulation Of Metabolic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Protein Modification Process
Negative Regulation Of Metabolic Process
P53 Binding
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Protein Stability
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Proteolysis
Nucleus
Regulation Of Cellular Response To Stress
Apoptotic Signaling Pathway
Protein Stabilization
Protein Modification By Small Protein Conjugation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
PML Body
Intrinsic Apoptotic Signaling Pathway
Intracellular Signal Transduction
Protein Kinase CK2 Complex
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Programmed Cell Death
Regulation Of Protein Modification Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Stress
Protein Metabolic Process
Post-translational Protein Modification
Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Post-translational Protein Modification
Negative Regulation Of Programmed Cell Death
Regulation Of Macromolecule Biosynthetic Process
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