PPP2R5A and CTLA4

Number of citations of the paper that reports this interaction (PMID 11994459)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vivo, two hybrid)

		PPP2R5A	CTLA4
Gene Name		protein phosphatase 2, regulatory subunit B, alpha	cytotoxic T-lymphocyte-associated protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Membrane Z Disc M Band	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase Type 2A Regulator Activity Kinase Binding	Protein Binding
	Biological Process	Signal Transduction Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Lipid Kinase Activity	Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway
Pathways		Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Mitotic Anaphase Signaling by Wnt M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling CTLA4 inhibitory signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Cell Cycle, Mitotic Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Mitotic Metaphase and Anaphase Adaptive Immune System	Costimulation by the CD28 family CTLA4 inhibitory signaling Adaptive Immune System
Drugs			Alpha-D-Mannose
Diseases
GWAS			Alopecia areata ( 20596022) Celiac disease ( 20190752) Graves' disease ( 21841780) Hypothyroidism ( 22493691) Rheumatoid arthritis ( 20453842 19503088) Type 1 diabetes ( 19430480 18978792) Type 1 diabetes autoantibodies ( 21829393)
Protein-Protein Interactions		18 interactors: APC BCL2 BEST1 CHEK2 CSNK1A1 CTLA4 EIF2AK2 GNL3 JAK2 MAPT NEK1 NOS3 PPP2R1A PTTG1 PYGM SGOL1 SHC1 TP63	14 interactors: AP1M1 AP2M1 CD80 CD86 FYN JAK2 LCK LYN PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TXK
Entrez ID		5525	1493
HPRD ID		03384	00474
Ensembl ID		ENSG00000066027	ENSG00000163599
Uniprot IDs		Q15172	P16410
PDB IDs			1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Cell Division Organelle Organization Cellular Response To Stress Mitotic Cell Cycle Regulation Of Protein Metabolic Process Mitotic Nuclear Division Positive Regulation Of Signal Transduction Cell Cycle Process Regulation Of Cell Proliferation Cellular Response To DNA Damage Stimulus Regulation Of Catalytic Activity Cell Cycle Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Apoptotic Process Positive Regulation Of Cell Death Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Phosphorus Metabolic Process Cell Death Negative Regulation Of Cell Proliferation Death Response To Stress Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Signal Transduction Response To Gamma Radiation Regulation Of Cell Differentiation Cytoskeleton Organization Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Response To Radiation Regulation Of Kinase Activity Negative Regulation Of Mitotic Cell Cycle Regulation Of Signaling Cell Aging Regulation Of Cell Cycle Phase Transition Regulation Of Phosphorylation Protein Phosphorylation Intracellular Signal Transduction Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Microtubule Polymerization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Activation Of Protein Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Activation T Cell Costimulation Regulation Of T Cell Activation Regulation Of Immune Response Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Immune System Process Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Hemopoiesis Positive Regulation Of Immune Response Neurotrophin TRK Receptor Signaling Pathway Lymphocyte Activation Peptidyl-tyrosine Autophosphorylation Cell Activation Response To Growth Hormone Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune System Development Response To Peptide Hormone Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Response To Peptide T Cell Aggregation Fc Receptor Signaling Pathway T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Phosphatidylinositol-mediated Signaling Regulation Of Cytokine Production Leukocyte Cell-cell Adhesion Viral Process Cellular Response To Organic Substance
Tagcloud ?			airway allergic asthma b7 bal blocking bronchoalveolar cd28 challenge challenges costimulation costimulatory engagement eosinophils eu hyperresponsiveness ige igg immunosuppressive infiltration inhalation lavage lymphocyte methacholine ovalbumin parabronchial sensitized tcr
Tagcloud (Difference) ?			airway allergic asthma b7 bal blocking bronchoalveolar cd28 challenge challenges costimulation costimulatory engagement eosinophils eu hyperresponsiveness ige igg immunosuppressive infiltration inhalation lavage lymphocyte methacholine ovalbumin parabronchial sensitized tcr
Tagcloud (Intersection) ?