PPP2R5A and CDCA2

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		PPP2R5A	CDCA2
Description		protein phosphatase 2 regulatory subunit B'alpha	cell division cycle associated 2
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GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Z Disc M Band	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Protein Binding Kinase Inhibitor Activity Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity	Protein Phosphatase Regulator Activity
	Biological Process	Signal Transduction Negative Regulation Of Protein Localization To Plasma Membrane	Chromosome Segregation Regulation Of Mitotic Nuclear Division Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation PKR-mediated signaling
Drugs
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) HDL cholesterol levels ( 32203549) Nickel levels ( 26025379) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) HDL cholesterol levels ( 32203549) Hip index ( 34021172) Major depressive disorder ( 27479909) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Systolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373) Triglyceride levels ( 32203549) Visceral adipose tissue volume ( 34128465)
Interacting Genes		28 interacting genes: APC AXIN2 BCL2 BEST1 BUB1B CDCA2 CHEK2 CSNK1A1 CTLA4 DAPK1 DZIP1 EIF2AK2 ERICH4 GNL3 JAK2 MAPT MOS NEK1 NOS3 PPFIA1 PPP2R1A PTTG1 SGO1 SHC1 SHFL TNNT2 TP63 USHBP1	4 interacting genes: CDK1 MBD4 PPP1CA PPP2R5A
Entrez ID		5525	157313
HPRD ID		03384	13014
Ensembl ID		ENSG00000066027	ENSG00000184661
Uniprot IDs		Q15172	A8K8Z0 B7Z5Q5 E9PEI0 Q69YH5
PDB IDs		6NTS 8SZK	5INB 5IOH 5SW9
Enriched GO Terms of Interacting Partners?		Cell Division Organelle Organization Protein Serine Kinase Activity Protein Kinase Activity Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Protein Serine/threonine Kinase Activity Kinase Activity Beta-catenin Destruction Complex Negative Regulation Of Osteoblast Proliferation Protein Phosphorylation Regulation Of Organelle Organization Protein Autophosphorylation Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Phosphorylation Chromosome Segregation Regulation Of Nuclear Division Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Cytosol Kinetochore Chromosome, Centromeric Region Centrosome Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Osteoblast Proliferation Regulation Of Protein Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Cytoskeleton Organization Negative Regulation Of Cell Cycle Phase Transition Protein Phosphatase Regulator Activity Regulation Of Mitotic Nuclear Division Sister Chromatid Cohesion Regulation Of Cell Cycle Phase Transition Cytoskeleton Microtubule Cytoskeleton Organization Nuclear Chromosome Segregation Chromosome Signal Transduction Nucleus Axon Development Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Regulation Of Signaling	DNA Metabolic Process Pronuclear Fusion Regulation Of Circadian Rhythm Mitotic DNA-templated DNA Replication DNA Damage Response DNA Repair Cyclin B1-CDK1 Complex Pyrimidine-containing Compound Metabolic Process Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Regulation Of Generation Of Precursor Metabolites And Energy RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Chromosome, Telomeric Region Cyclin-dependent Protein Kinase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Satellite DNA Binding Thymidine Metabolic Process Golgi Disassembly Nuclear DNA Replication Rhythmic Process Thymidine Biosynthetic Process Histone Kinase Activity Glycogen Granule PTW/PP1 Phosphatase Complex Kinase Inhibitor Activity Phosphate-containing Compound Metabolic Process RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Depyrimidination Response To Metal Ion Positive Regulation Of Mitotic Sister Chromatid Segregation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromosome Organization Ventricular Cardiac Muscle Cell Development Regulation Of Translational Initiation In Response To Stress Double-strand Break Repair Via Alternative Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand DNA N-glycosylase Activity Mitotic Nuclear Membrane Disassembly Cilium Disassembly Cellular Response To Stress Pyrimidine Nucleoside Metabolic Process
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