PPP2R5A and MOS

Number of citations of the paper that reports this interaction (PubMedID 32707033)
104

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PPP2R5A	MOS
Description		protein phosphatase 2 regulatory subunit B'alpha	MOS proto-oncogene, serine/threonine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Z Disc M Band	Cytoplasm
	Molecular Function	Protein Binding Kinase Inhibitor Activity Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction Negative Regulation Of Protein Localization To Plasma Membrane	MAPK Cascade Meiotic Spindle Organization Oocyte Maturation Chromatin Organization Signal Transduction Regulation Of Meiotic Nuclear Division Positive Regulation Of MAPK Cascade Establishment Of Meiotic Spindle Orientation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation PKR-mediated signaling
Drugs
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) HDL cholesterol levels ( 32203549) Nickel levels ( 26025379) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Height ( 18391951) Refractive error ( 32231278)
Interacting Genes		28 interacting genes: APC AXIN2 BCL2 BEST1 BUB1B CDCA2 CHEK2 CSNK1A1 CTLA4 DAPK1 DZIP1 EIF2AK2 ERICH4 GNL3 JAK2 MAPT MOS NEK1 NOS3 PPFIA1 PPP2R1A PTTG1 SGO1 SHC1 SHFL TNNT2 TP63 USHBP1	57 interacting genes: ACTN2 ASB6 ATRIP BICD2 BMPR2 BORCS6 CALCOCO2 CBY2 CCDC102B CCDC136 CCDC33 CCNDBP1 CFTR DYDC1 DZIP1 GFAP GOLGA2 GOLGA6A GOLGA6L9 GRAP2 HOMER3 HOMEZ HSPA1A IKZF1 KCTD6 KIFAP3 KIFC3 KRT13 KRT15 KRT27 KRT31 KRT33B KRT34 KRT40 KRTAP1-3 LZTS2 MAP2K2 MEOX2 MID2 MIPOL1 MTMR9 MTUS2 MYOD1 NBPF19 NOTCH2NLA PICK1 PPP2R5A PSTPIP1 RHOU SEC24C SSX2IP TP53BP2 TRAF1 TRAF2 TRIM27 USHBP1 ZBTB2
Entrez ID		5525	4342
HPRD ID		03384	01816
Ensembl ID		ENSG00000066027	ENSG00000172680
Uniprot IDs		Q15172	P00540
PDB IDs		6NTS 8SZK
Enriched GO Terms of Interacting Partners?		Cell Division Organelle Organization Protein Serine Kinase Activity Protein Kinase Activity Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Protein Serine/threonine Kinase Activity Kinase Activity Beta-catenin Destruction Complex Negative Regulation Of Osteoblast Proliferation Protein Phosphorylation Regulation Of Organelle Organization Protein Autophosphorylation Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Phosphorylation Chromosome Segregation Regulation Of Nuclear Division Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Cytosol Kinetochore Chromosome, Centromeric Region Centrosome Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Osteoblast Proliferation Regulation Of Protein Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Cytoskeleton Organization Negative Regulation Of Cell Cycle Phase Transition Protein Phosphatase Regulator Activity Regulation Of Mitotic Nuclear Division Sister Chromatid Cohesion Regulation Of Cell Cycle Phase Transition Cytoskeleton Microtubule Cytoskeleton Organization Nuclear Chromosome Segregation Chromosome Signal Transduction Nucleus Axon Development Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Regulation Of Signaling	Structural Constituent Of Skin Epidermis Cytoskeleton Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Identical Protein Binding Cytosol Cytoskeleton Organization Protein Binding Epithelial Cell Differentiation Morphogenesis Of An Epithelium Organelle Organization Centrosome Tissue Morphogenesis Thioesterase Binding Cytoplasm Golgi Cis Cisterna
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