SCNN1B and HECW1

Number of citations of the paper that reports this interaction (PubMedID 11244092)
0

Data Source:
BioGRID (far western blotting)

		SCNN1B	HECW1
Description		sodium channel epithelial 1 subunit beta	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Sodium Channel Complex Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Renal System Process Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Artery Smooth Muscle Contraction Response To Food Aldosterone Metabolic Process Erythrocyte Homeostasis Monoatomic Ion Transmembrane Transport Multicellular Organism Growth Sodium Ion Transmembrane Transport Epithelial Fluid Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Potassium Ion Homeostasis Sodium Ion Homeostasis Mucus Secretion Neutrophil-mediated Killing Of Bacterium Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Stimuli-sensing channels Sensory perception of salty taste	Degradation of DVL
Drugs		Triamterene Amiloride
Diseases		Liddle syndrome Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Kidney stones ( 31729369)	Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)
Interacting Genes		14 interacting genes: ANK3 CNTN1 COMMD10 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2	19 interacting genes: CACNA1A DVL1 GFI1B PRRG4 SCNN1A SCNN1B SHANK3 SSR4 TNK2 TP53 TSC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1
Entrez ID		6338	23072
HPRD ID		02861	11385
Ensembl ID		ENSG00000168447	ENSG00000002746
Uniprot IDs		B2R812 H3BQ95 P51168	Q76N89
PDB IDs		6BQN 6WTH 9BLR 9BTG 9BTU	3L4H
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Sensory Perception Of Salty Taste Negative Regulation Of Potassium Ion Transport Import Into Cell Negative Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Aldosterone Sodium Channel Complex Sensory Perception Of Sour Taste Cellular Response To Vasopressin Potassium Channel Inhibitor Activity Transmembrane Transporter Binding Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Response To Aldosterone Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Acidic PH Regulation Of Potassium Ion Transport Intracellular Sodium Ion Homeostasis Inorganic Cation Import Across Plasma Membrane Negative Regulation Of Monoatomic Ion Transport Response To Acidic PH Ubiquitin-protein Transferase Activity Cellular Response To PH Negative Regulation Of Transmembrane Transport Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Homeostasis Neuromuscular Junction Development Response To Mineralocorticoid Sodium Ion Transmembrane Transport Response To PH Import Across Plasma Membrane Regulation Of Metal Ion Transport Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Monoubiquitination Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Sodium Channel Inhibitor Activity Regulation Of Dendrite Morphogenesis Endocytosis Cellular Response To Corticosteroid Stimulus Receptor Internalization Protein K63-linked Ubiquitination	Ubiquitin Conjugating Enzyme Activity WW Domain Binding Protein Ubiquitination Sensory Perception Of Salty Taste Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Polyubiquitination Cellular Response To Aldosterone Sodium Channel Complex Ubiquitin Protein Ligase Binding Post-translational Protein Modification Proteolysis Modification-dependent Protein Catabolic Process Regulation Of Protein Targeting To Mitochondrion Sensory Perception Of Sour Taste Cellular Response To Vasopressin TORC1 Signaling Cellular Response To Corticosteroid Stimulus Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Negative Regulation Of ATP-dependent Activity Negative Regulation Of Neuroblast Proliferation Cellular Response To Steroid Hormone Stimulus TOR Signaling Protein Stabilization Negative Regulation Of TOR Signaling Inorganic Cation Import Across Plasma Membrane Response To Nutrient Levels Ubiquitin-protein Transferase Activity Response To Aldosterone Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Dendritic Spine Morphogenesis Cellular Response To Acidic PH Negative Regulation Of Autophagy Protein K48-linked Ubiquitination Intracellular Sodium Ion Homeostasis Ubiquitin-dependent Protein Catabolic Process Sodium Ion Import Across Plasma Membrane Response To Acidic PH Protein K6-linked Ubiquitination Cellular Response To PH Negative Regulation Of Neural Precursor Cell Proliferation Multicellular Organismal-level Water Homeostasis Import Across Plasma Membrane Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization
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