SCNN1B and SCNN1G

Number of citations of the paper that reports this interaction (PubMedID 8986818)
27

Data Source:
HPRD (in vivo)

		SCNN1B	SCNN1G
Description		sodium channel epithelial 1 subunit beta	sodium channel epithelial 1 subunit gamma
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Sodium Channel Complex Extracellular Exosome	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Sodium Channel Complex Extracellular Exosome
	Molecular Function	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Monoatomic Ion Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Renal System Process Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Artery Smooth Muscle Contraction Response To Food Aldosterone Metabolic Process Erythrocyte Homeostasis Monoatomic Ion Transmembrane Transport Multicellular Organism Growth Sodium Ion Transmembrane Transport Epithelial Fluid Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Potassium Ion Homeostasis Sodium Ion Homeostasis Mucus Secretion Neutrophil-mediated Killing Of Bacterium Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin	Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Sodium Ion Homeostasis Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin
Pathways		Stimuli-sensing channels Sensory perception of salty taste	Stimuli-sensing channels Sensory perception of salty taste
Drugs		Triamterene Amiloride	Triamterene Amiloride
Diseases		Liddle syndrome Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)	Liddle syndrome Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Kidney stones ( 31729369)	Heel bone mineral density ( 30598549) Parent of origin effect on receptive language ability (paternal) ( 32635940)
Interacting Genes		14 interacting genes: ANK3 CNTN1 COMMD10 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2	13 interacting genes: COMMD10 EPN1 MAPK1 NEDD4 NEDD4L SCNN1A SCNN1B SCNN1D SERP1 SOX4 STX1A USP10 WWP2
Entrez ID		6338	6340
HPRD ID		02861	02862
Ensembl ID		ENSG00000168447	ENSG00000166828
Uniprot IDs		B2R812 H3BQ95 P51168	A5X2V1 P51170
PDB IDs		6BQN 6WTH 9BLR 9BTG 9BTU	6BQN 6WTH 9BLR 9BTG 9BTU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Sensory Perception Of Salty Taste Negative Regulation Of Potassium Ion Transport Import Into Cell Negative Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Aldosterone Sodium Channel Complex Sensory Perception Of Sour Taste Cellular Response To Vasopressin Potassium Channel Inhibitor Activity Transmembrane Transporter Binding Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Response To Aldosterone Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Acidic PH Regulation Of Potassium Ion Transport Intracellular Sodium Ion Homeostasis Inorganic Cation Import Across Plasma Membrane Negative Regulation Of Monoatomic Ion Transport Response To Acidic PH Ubiquitin-protein Transferase Activity Cellular Response To PH Negative Regulation Of Transmembrane Transport Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Homeostasis Neuromuscular Junction Development Response To Mineralocorticoid Sodium Ion Transmembrane Transport Response To PH Import Across Plasma Membrane Regulation Of Metal Ion Transport Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Monoubiquitination Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Sodium Channel Inhibitor Activity Regulation Of Dendrite Morphogenesis Endocytosis Cellular Response To Corticosteroid Stimulus Receptor Internalization Protein K63-linked Ubiquitination	Import Into Cell Sodium Ion Import Across Plasma Membrane Sensory Perception Of Salty Taste Negative Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Aldosterone Sodium Channel Complex Sensory Perception Of Sour Taste Cellular Response To Vasopressin Transmembrane Transporter Binding Potassium Channel Inhibitor Activity Regulation Of Biological Quality Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Sodium Ion Transport Response To Aldosterone Cellular Response To Acidic PH Negative Regulation Of Potassium Ion Transmembrane Transport Intracellular Sodium Ion Homeostasis Inorganic Cation Import Across Plasma Membrane Response To Acidic PH Cellular Response To PH Negative Regulation Of Potassium Ion Transport Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Transmembrane Transport Sodium Ion Homeostasis Response To Mineralocorticoid Response To PH Import Across Plasma Membrane Protein Monoubiquitination Endocytosis Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Intracellular Chemical Homeostasis Cellular Response To Steroid Hormone Stimulus Regulation Of Potassium Ion Transport Negative Regulation Of Sodium Ion Transport Metal Ion Transport Negative Regulation Of Monoatomic Ion Transport Regulation Of Transport Protein Modification Process Sensory Perception Of Chemical Stimulus Cellular Homeostasis Negative Regulation Of Transmembrane Transport Receptor Catabolic Process Protein Modification By Small Protein Conjugation
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