DAG1 and LAMA2

Number of citations of the paper that reports this interaction (PubMedID 16709410)
0

Data Source:
HPRD (in vitro, in vivo)

		DAG1	LAMA2
Description		dystroglycan 1	laminin subunit alpha 2
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Basement Membrane Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Lumen Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Membrane Basolateral Plasma Membrane Lamellipodium Filopodium Extracellular Matrix Node Of Ranvier Nuclear Periphery Sarcolemma Costamere Plasma Membrane Raft Membrane Raft Synapse Postsynaptic Membrane Extracellular Exosome Contractile Ring Photoreceptor Ribbon Synapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol	Extracellular Region Basement Membrane Extracellular Matrix Neuromuscular Junction Sarcolemma Synaptic Cleft Dendritic Spine Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Virus Receptor Activity Dystroglycan Binding Actin Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Tubulin Binding Vinculin Binding SH2 Domain Binding Laminin Binding Laminin-1 Binding Protein-containing Complex Binding Alpha-actinin Binding	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Morphogenesis Of An Epithelium Morphogenesis Of An Epithelial Sheet Heart Morphogenesis Membrane Protein Ectodomain Proteolysis Axon Guidance Heart Development Schwann Cell Differentiation Schwann Cell Development Response To Muscle Activity Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Transport Muscle Attachment Calcium-dependent Cell-matrix Adhesion Nerve Development Nerve Maturation Myelination In Peripheral Nervous System Extracellular Matrix Organization Negative Regulation Of Cell Migration Axon Regeneration Positive Regulation Of Myelination Microtubule Anchoring Skeletal Muscle Tissue Regeneration Negative Regulation Of MAPK Cascade Response To Peptide Hormone Symbiont Entry Into Host Cell Regulation Of Synaptic Plasticity Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Synapse Organization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Cellular Response To Mechanical Stimulus Cellular Response To Cholesterol Commissural Neuron Axon Guidance Basement Membrane Organization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex	Cell Adhesion Axon Guidance Muscle Organ Development Schwann Cell Differentiation Regulation Of Cell Adhesion Regulation Of Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Maintenance Of Blood-brain Barrier Positive Regulation Of Cell Adhesion Regulation Of Embryonic Development Positive Regulation Of Muscle Cell Differentiation Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 core M2 glycosylations DAG1 core M3 glycosylations DAG1 core M1 glycosylations Regulation of expression of SLITs and ROBOs EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Matriglycan biosynthesis on DAG1	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans MET activates PTK2 signaling EGR2 and SOX10-mediated initiation of Schwann cell myelination Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD)	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		A body shape index ( 34021172) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Resting heart rate ( 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) Axial length ( 24144296) Body mass index ( 20397748) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 31562340) High myopia ( 33830181 31816047) Hyperopia ( 25233373 33830181) Low myopia vs hyperopia ( 33830181) Metabolite levels ( 23823483) Myopia ( 25233373 27182965) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629) Refractive error ( 23396134) Retinal detachment or retinal break ( 31816047) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Sleep duration (short sleep) ( 30846698) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tea consumption ( 31046077)
Interacting Genes		26 interacting genes: AGR2 AGR3 AGRN BGN CAV1 CAV3 DMD DRP2 FYN GRB2 HMGB1 ITGB1 LAMA1 LAMA2 LAMA5 MAGI1 MAP2 NCK1 RAPSN SHC1 SRC TLN1 TUBA1A UTRN WWP1 WWP2	4 interacting genes: DAG1 RPSA SNAPIN TRIM63
Entrez ID		1605	3908
HPRD ID		00546	01125
Ensembl ID		ENSG00000173402	ENSG00000196569
Uniprot IDs		Q14118	A0A087WYF1 P24043 Q59H37
PDB IDs		1EG4 2MK7 5GGP 5LLK 6JJY 7E9K 7E9L	4YEP 4YEQ
Enriched GO Terms of Interacting Partners?		Dystroglycan Binding Neuromuscular Junction Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Ephrin Receptor Binding Sarcolemma Muscle Organ Development Muscle Structure Development Regulation Of Cellular Component Organization Integrin Binding Developmental Process Plasma Membrane Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Membrane Raft Nitric-oxide Synthase Binding T Cell Costimulation Regulation Of Metal Ion Transport Positive Regulation Of Cell-cell Adhesion Vinculin Binding Extracellular Matrix Structural Constituent Regulation Of Cell Migration Symbiont Entry Into Host Cell Regulation Of Multicellular Organismal Process Cytoskeleton Organization Regulation Of Cell Motility Dystrophin-associated Glycoprotein Complex Signaling Receptor Binding Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Anoikis Cell Projection Organization Animal Organ Development Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Adhesion Biological Process Involved In Interaction With Host Receptor Internalization Plasma Membrane Bounded Cell Projection Organization Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Organelle Organization Regulation Of Anoikis	Laminin Binding Muscle Attachment Symbiont Entry Into Host Cell Virus Receptor Activity Positive Regulation Of Late Endosome To Lysosome Transport Calcium-dependent Cell-matrix Adhesion Biological Process Involved In Interaction With Host Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Developmental Maturation Protein Metabolic Process Laminin Receptor Activity Response To Denervation Involved In Regulation Of Muscle Adaptation Trans-synaptic Signaling By Trans-synaptic Complex Laminin-1 Binding Schwann Cell Differentiation Photoreceptor Ribbon Synapse Dystroglycan Complex Contractile Ring Terminal Button Organization Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Response To Muscle Inactivity Synaptic Vesicle Maturation Regulation Of Lysosome Size BORC Complex Microvesicle Muscle Atrophy Dystroglycan Binding Trans-synaptic Signaling Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Branching Involved In Salivary Gland Morphogenesis Costamere Vinculin Binding Cellular Response To Sterol Dystrophin-associated Glycoprotein Complex Neuron Projection Development Node Of Ranvier Schwann Cell Development Nuclear Periphery Skeletal Muscle Tissue Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Commissural Neuron Axon Guidance Angiogenesis Involved In Wound Healing Axon Regeneration Morphogenesis Of An Epithelial Sheet Positive Regulation Of Myelination Alpha-actinin Binding
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