DAG1 and LAMA5

Number of citations of the paper that reports this interaction (PubMedID 10207021)
0

Data Source:
HPRD (in vitro)

		DAG1	LAMA5
Description		dystroglycan 1	laminin subunit alpha 5
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Basement Membrane Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Lumen Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Membrane Basolateral Plasma Membrane Lamellipodium Filopodium Extracellular Matrix Node Of Ranvier Nuclear Periphery Sarcolemma Costamere Plasma Membrane Raft Membrane Raft Synapse Postsynaptic Membrane Extracellular Exosome Contractile Ring Photoreceptor Ribbon Synapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Space Nucleus Extracellular Matrix Neuromuscular Junction Synaptic Cleft Laminin-10 Complex Laminin-11 Complex Extracellular Exosome Extracellular Matrix Of Synaptic Cleft Glutamatergic Synapse
	Molecular Function	Virus Receptor Activity Dystroglycan Binding Actin Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Tubulin Binding Vinculin Binding SH2 Domain Binding Laminin Binding Laminin-1 Binding Protein-containing Complex Binding Alpha-actinin Binding	Signaling Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Receptor Ligand Activity Cell Adhesion Mediator Activity
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Morphogenesis Of An Epithelium Morphogenesis Of An Epithelial Sheet Heart Morphogenesis Membrane Protein Ectodomain Proteolysis Axon Guidance Heart Development Schwann Cell Differentiation Schwann Cell Development Response To Muscle Activity Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Transport Muscle Attachment Calcium-dependent Cell-matrix Adhesion Nerve Development Nerve Maturation Myelination In Peripheral Nervous System Extracellular Matrix Organization Negative Regulation Of Cell Migration Axon Regeneration Positive Regulation Of Myelination Microtubule Anchoring Skeletal Muscle Tissue Regeneration Negative Regulation Of MAPK Cascade Response To Peptide Hormone Symbiont Entry Into Host Cell Regulation Of Synaptic Plasticity Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Synapse Organization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Cellular Response To Mechanical Stimulus Cellular Response To Cholesterol Commissural Neuron Axon Guidance Basement Membrane Organization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex	Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Kidney Development Hair Follicle Development Cell Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Animal Organ Morphogenesis Morphogenesis Of Embryonic Epithelium Cell Migration Regulation Of Cell Adhesion Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Trunk Neural Crest Cell Migration Odontogenesis Of Dentin-containing Tooth Regulation Of Embryonic Development Skeletal System Morphogenesis System Development Branching Morphogenesis Of An Epithelial Tube Regulation Of Epithelial Cell Proliferation Cilium Assembly Branching Involved In Salivary Gland Morphogenesis Protein Localization To Plasma Membrane Postsynapse Organization
Pathways		Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 core M2 glycosylations DAG1 core M3 glycosylations DAG1 core M1 glycosylations Regulation of expression of SLITs and ROBOs EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Matriglycan biosynthesis on DAG1	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs			Lanoteplase
Diseases		Limb-girdle muscular dystrophy (LGMD)
GWAS		A body shape index ( 34021172) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Resting heart rate ( 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)	Colorectal cancer ( 20972440 24737748 25990418) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Neuroblastoma (pediatric) ( 32599975) Pelvic organ prolapse ( 26545240) Plateletcrit ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		26 interacting genes: AGR2 AGR3 AGRN BGN CAV1 CAV3 DMD DRP2 FYN GRB2 HMGB1 ITGB1 LAMA1 LAMA2 LAMA5 MAGI1 MAP2 NCK1 RAPSN SHC1 SRC TLN1 TUBA1A UTRN WWP1 WWP2	16 interacting genes: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 HOXA1 LAMC1 MEP1A MTDH MYOC SMAD2 SV2A UBC USP4
Entrez ID		1605	3911
HPRD ID		00546	03020
Ensembl ID		ENSG00000173402	ENSG00000130702
Uniprot IDs		Q14118	O15230
PDB IDs		1EG4 2MK7 5GGP 5LLK 6JJY 7E9K 7E9L	5XAU 7CEC
Enriched GO Terms of Interacting Partners?		Dystroglycan Binding Neuromuscular Junction Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Ephrin Receptor Binding Sarcolemma Muscle Organ Development Muscle Structure Development Regulation Of Cellular Component Organization Integrin Binding Developmental Process Plasma Membrane Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Membrane Raft Nitric-oxide Synthase Binding T Cell Costimulation Regulation Of Metal Ion Transport Positive Regulation Of Cell-cell Adhesion Vinculin Binding Extracellular Matrix Structural Constituent Regulation Of Cell Migration Symbiont Entry Into Host Cell Regulation Of Multicellular Organismal Process Cytoskeleton Organization Regulation Of Cell Motility Dystrophin-associated Glycoprotein Complex Signaling Receptor Binding Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Anoikis Cell Projection Organization Animal Organ Development Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Adhesion Biological Process Involved In Interaction With Host Receptor Internalization Plasma Membrane Bounded Cell Projection Organization Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Organelle Organization Regulation Of Anoikis	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Extracellular Matrix Constituent Conferring Elasticity Basement Membrane Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Myelination In Peripheral Nervous System Node Of Ranvier Laminin Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Cholesterol Extracellular Space Cell-substrate Adhesion Endoderm Development Positive Regulation Of Intracellular Signal Transduction Collagen Type VII Trimer Regulation Of Cell Adhesion RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Attachment Semicircular Canal Formation Skeletal Muscle Hypertrophy Adenosine Receptor Binding Regulation Of Signal Transduction Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Region Endoplasmic Reticulum Lumen Heart Development Helper T Cell Diapedesis Chordate Pharynx Development Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Communication Cerebellar Neuron Development Regulation Of Intracellular Signal Transduction Receptor Tyrosine Kinase Binding Neuromuscular Junction Regulation Of Signaling Response To Transforming Growth Factor Beta Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Positive Regulation Of Cell-matrix Adhesion Calcium-dependent Cell-matrix Adhesion Peptide Hormone Secretion Endothelin B Receptor Binding Peptide Secretion Abducens Nerve Formation
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