KLF2 and GATA5

Number of citations of the paper that reports this interaction (PubMedID 11375995)
0

Data Source:
BioGRID (two hybrid)

		KLF2	GATA5
Description		KLF transcription factor 2	GATA binding protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Interleukin-6 Production Erythrocyte Homeostasis Response To Laminar Fluid Shear Stress Multicellular Organism Growth Epigenetic Regulation Of Gene Expression Vasodilation Erythrocyte Maturation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Type I Pneumocyte Differentiation Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Cellular Stress Response To Acid Chemical Negative Regulation Of Sprouting Angiogenesis Cellular Response To Endothelin	Negative Regulation Of Transcription By RNA Polymerase II Heart Induction Aortic Valve Morphogenesis Endocardial Cushion Fusion Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Heart Development Anatomical Structure Morphogenesis Tissue Development Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Cell Fate Commitment Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Intestinal Epithelial Cell Differentiation Positive Regulation Of Cardiac Endothelial To Mesenchymal Transition Cellular Response To Hydrogen Peroxide Cellular Response To Nitric Oxide Cellular Response To BMP Stimulus Positive Regulation Of Apoptotic DNA Fragmentation
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Asthma ( 32296059) Coronary artery disease ( 33020668) Depression in smokers ( 30219690) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Systemic lupus erythematosus ( 33493351) White blood cell count ( 32888494)	Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Central serous retinopathy ( 31872073) Chronic central serous retinopathy ( 30073298) Hematocrit ( 32888494) Hemoglobin ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		7 interacting genes: EP300 GATA5 GATA6 GSK3B KAT2B PSME3 WWP1	10 interacting genes: ARID5A CYSRT1 EP300 HNF1A HPCA HPCAL1 KLF2 MAGED1 PLA2G10 PPARG
Entrez ID		10365	140628
HPRD ID		03602	17029
Ensembl ID		ENSG00000127528	ENSG00000130700
Uniprot IDs		Q9Y5W3	Q9BWX5
PDB IDs
Enriched GO Terms of Interacting Partners?		N-terminal Peptidyl-lysine Acetylation P53 Binding L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation TORC2 Signaling N-terminal Protein Amino Acid Acetylation Striated Muscle Tissue Development Regulation Of Cellular Response To Heat Peptidyl-lysine Acetylation Regulation Of TORC2 Signaling Regulation Of Generation Of Precursor Metabolites And Energy Intestinal Epithelial Cell Differentiation Muscle Tissue Development Acetyltransferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Complex Cell Fate Commitment Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein-lysine-acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Cellular Response To BMP Stimulus NF-kappaB Binding Protein Acetylation Endodermal Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Rhythmic Process Cellular Response To Stress Heart Development Tau Protein Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression, Epigenetic Cellular Response To Oxygen-containing Compound Regulation Of DNA-templated Transcription Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Gluconeogenesis Transcription Initiation-coupled Chromatin Remodeling	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of T-helper 17 Type Immune Response STAT Family Protein Binding Nuclear Retinoid X Receptor Binding Erythrocyte Maturation Cellular Response To Oxygen-containing Compound Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Maturation Regulation Of Transcription By RNA Polymerase II Nuclear Androgen Receptor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macrophage Derived Foam Cell Differentiation Chromatin Positive Regulation Of RNA Metabolic Process Developmental Maturation Regulation Of T-helper 17 Type Immune Response Transcription Coregulator Binding Response To Hormone Regulation Of Cholesterol Efflux Positive Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Positive Regulation Of Transcription By RNA Polymerase II Long-chain Fatty Acid Transport Regulation Of Lipid Storage Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Peptidyl-lysine Propionylation Regulation Of RNA Biosynthetic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Negative Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Response To Estrogen Regulation Of Cholesterol Transport Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Histone H2B Acetyltransferase Activity Regulation Of RNA Metabolic Process Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity
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