KLF2

Description		KLF transcription factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Interleukin-6 Production Erythrocyte Homeostasis Response To Laminar Fluid Shear Stress Multicellular Organism Growth Epigenetic Regulation Of Gene Expression Vasodilation Erythrocyte Maturation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Type I Pneumocyte Differentiation Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Cellular Stress Response To Acid Chemical Negative Regulation Of Sprouting Angiogenesis Cellular Response To Endothelin
Pathways
Drugs
Diseases
GWAS		Asthma ( 32296059) Coronary artery disease ( 33020668) Depression in smokers ( 30219690) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Systemic lupus erythematosus ( 33493351) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: EP300 GATA5 GATA6 GSK3B KAT2B PSME3 WWP1
Entrez ID		10365
HPRD ID		03602
Ensembl ID		ENSG00000127528
Uniprot IDs		Q9Y5W3
PDB IDs
Enriched GO Terms of Interacting Partners?		N-terminal Peptidyl-lysine Acetylation P53 Binding L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation TORC2 Signaling N-terminal Protein Amino Acid Acetylation Striated Muscle Tissue Development Regulation Of Cellular Response To Heat Peptidyl-lysine Acetylation Regulation Of TORC2 Signaling Regulation Of Generation Of Precursor Metabolites And Energy Intestinal Epithelial Cell Differentiation Muscle Tissue Development Acetyltransferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Complex Cell Fate Commitment Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein-lysine-acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Cellular Response To BMP Stimulus NF-kappaB Binding Protein Acetylation Endodermal Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Rhythmic Process Cellular Response To Stress Heart Development Tau Protein Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression, Epigenetic Cellular Response To Oxygen-containing Compound Regulation Of DNA-templated Transcription Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Gluconeogenesis Transcription Initiation-coupled Chromatin Remodeling
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