KLF2 and PSME3

Number of citations of the paper that reports this interaction (PubMedID 26776519)
56

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		KLF2	PSME3
Description		KLF transcription factor 2	proteasome activator subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Proteasome Activator Complex Membrane Ciliary Basal Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	P53 Binding Protein Binding Identical Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Interleukin-6 Production Erythrocyte Homeostasis Response To Laminar Fluid Shear Stress Multicellular Organism Growth Epigenetic Regulation Of Gene Expression Vasodilation Erythrocyte Maturation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Type I Pneumocyte Differentiation Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Cellular Stress Response To Acid Chemical Negative Regulation Of Sprouting Angiogenesis Cellular Response To Endothelin	Apoptotic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Proteasome assembly
Drugs
Diseases
GWAS		Asthma ( 32296059) Coronary artery disease ( 33020668) Depression in smokers ( 30219690) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Systemic lupus erythematosus ( 33493351) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: EP300 GATA5 GATA6 GSK3B KAT2B PSME3 WWP1	63 interacting genes: ABCF3 ADAP1 AICDA ATN1 ATP5F1B BBS2 CASP3 CASP6 CASP7 CDC25B CDC42 CEBPA CHEK2 COIL CREBBP DEPTOR DIP2A DMRT3 DTNBP1 DVL3 EAF1 EAF2 FAM90A1 FBXL12 FMR1 FOXD4L1 FXR1 FXR2 GPATCH2L HSPA5 INPP5J ITPKB KANSL1 KBTBD7 KLF2 LNX1 MDM2 MEOX2 NCOA3 NTAQ1 NUDT18 PFDN5 PICK1 PRKAB2 PRR13 RDX RNF111 RPH3AL RPS27 SERF2 SIRT1 SMURF1 SPG7 TBXA2R THAP10 TNFAIP8L1 TP53 TXN2 UBE2H UBE2I WDR25 YWHAQ ZCCHC10
Entrez ID		10365	10197
HPRD ID		03602	05500
Ensembl ID		ENSG00000127528	ENSG00000131467
Uniprot IDs		Q9Y5W3	B3KQ25 P61289 V9HWJ8
PDB IDs			7YQC 7YQD
Enriched GO Terms of Interacting Partners?		N-terminal Peptidyl-lysine Acetylation P53 Binding L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation TORC2 Signaling N-terminal Protein Amino Acid Acetylation Striated Muscle Tissue Development Regulation Of Cellular Response To Heat Peptidyl-lysine Acetylation Regulation Of TORC2 Signaling Regulation Of Generation Of Precursor Metabolites And Energy Intestinal Epithelial Cell Differentiation Muscle Tissue Development Acetyltransferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Complex Cell Fate Commitment Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein-lysine-acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Cellular Response To BMP Stimulus NF-kappaB Binding Protein Acetylation Endodermal Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Rhythmic Process Cellular Response To Stress Heart Development Tau Protein Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression, Epigenetic Cellular Response To Oxygen-containing Compound Regulation Of DNA-templated Transcription Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Gluconeogenesis Transcription Initiation-coupled Chromatin Remodeling	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cellular Response To Staurosporine Response To Nutrient Levels Protein Binding Protein Domain Specific Binding Nucleus Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Response To Nutrient Levels Macromolecule Catabolic Process Cytosol Positive Regulation Of Protein Metabolic Process Cellular Response To Alkaloid Post-translational Protein Modification Response To Xenobiotic Stimulus Neuron Projection Response To Alkaloid Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Leukocyte Apoptotic Process Response To UV Proteolysis Regulation Of Protein Metabolic Process Signal Transduction By P53 Class Mediator Mononuclear Cell Differentiation Protein-containing Complex Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Translation Regulator Activity Cellular Response To Glucose Starvation Cellular Response To Actinomycin D Positive Regulation Of Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Developmental Process Modification-dependent Protein Catabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of RNA Metabolic Process Protein Destabilization Response To Actinomycin D HLH Domain Binding Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Stability Leukocyte Differentiation Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MiRNA-mediated Gene Silencing Disordered Domain Specific Binding Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process
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