TLK2 and FEZ2

Number of citations of the paper that reports this interaction (PubMedID 16484223)
0

Data Source:
BioGRID (two hybrid)

		TLK2	FEZ2
Description		tousled like kinase 2	fasciculation and elongation protein zeta 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Intermediate Filament Perinuclear Region Of Cytoplasm	Cytoplasm Axon
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Chromatin Organization Protein Phosphorylation DNA Damage Response Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Nucleus Localization Cellular Response To Gamma Radiation Regulation Of Chromatin Organization	Signal Transduction Nervous System Development Axon Guidance Negative Regulation Of Autophagosome Assembly
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lifespan ( 25918517) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Apolipoprotein A1 levels ( 32203549) Haemorrhoidal disease ( 33888516) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ	18 interacting genes: BRD1 CLASP2 DRAP1 FEZ1 KPNA2 NEK1 PDCD7 PRKCZ RAB3GAP1 RAI14 SAP30L SMC3 STIP1 TBC1D25 TEDC2 TLK2 WWC1 ZNF251
Entrez ID		11011	9637
HPRD ID		10527	09213
Ensembl ID		ENSG00000146872	ENSG00000171055
Uniprot IDs		A0A804HJZ9 A0A804HK10 B4DUC2 J3QLK5 Q86UE8	Q9UHY8
PDB IDs		5O0Y 7LO0
Enriched GO Terms of Interacting Partners?		Chromatin Organization DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Regulation Of Vacuole Organization Negative Regulation Of Autophagosome Assembly Histone Chaperone Activity Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Toll-like Receptor Signaling Pathway Chromatin Positive Regulation Of Metalloendopeptidase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding SUMO Conjugating Enzyme Activity Negative Regulation Of Macroautophagy Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Gamma-tubulin Binding Nucleus Regulation Of Autophagosome Assembly	Establishment Or Maintenance Of Cell Polarity Establishment Of Cell Polarity
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