TLK2 and IRF4

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TLK2	IRF4
Gene Name		tousled-like kinase 2	interferon regulatory factor 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm	Nuclear Nucleosome Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein-lysine N-methyltransferase Activity Sequence-specific DNA Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Chromatin Modification Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation	Transcription, DNA-templated Peptidyl-lysine Methylation Cytokine-mediated Signaling Pathway Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway T-helper 17 Cell Lineage Commitment
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Celiac disease ( 20190752) Chronic lymphocytic leukemia ( 18758461) Eye color ( 20585627) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627) Hematology traits ( 23303382) Non-melanoma skin cancer ( 23548203) Progressive supranuclear palsy ( 21685912) Sunburns ( 23548203) Tanning ( 23548203)
Protein-Protein Interactions		10 interactors: ASF1A ASF1B AURKA FEZ1 FEZ2 IRF4 IRF7 MBP TLK1 YWHAZ	19 interactors: BATF BCL6 ETV7 FKBP4 HOXB13 HOXC11 IKBKAP IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 YTHDC2
Entrez ID		11011	3662
HPRD ID		10527	03543
Ensembl ID			ENSG00000137265
Uniprot IDs		Q86UE8	Q15306
PDB IDs			2DLL
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization DNA Replication-dependent Nucleosome Assembly Chromosome Organization Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-4 Production DNA Replication-independent Nucleosome Assembly Cell Differentiation Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cell Differentiation Positive Regulation Of Cytokine Production Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of Spindle Checkpoint Positive Regulation Of Interleukin-13 Biosynthetic Process Response To External Stimulus Organelle Localization Regulation Of Cellular Component Organization Organelle Organization Spindle Assembly Involved In Female Meiosis I Positive Regulation Of Interleukin-10 Biosynthetic Process MDA-5 Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Cellular Process Response To Stress Nucleosome Assembly Gene Expression Interferon-gamma-mediated Signaling Pathway Regulation Of Cytokine Production Spindle Assembly Involved In Meiosis Defense Response To Nematode Interferon-beta Production Immune Response Transcription, DNA-templated Chromatin Assembly Defense Response Nucleosome Organization Interferon-alpha Production Negative Regulation Of Macrophage Apoptotic Process Golgi Reassembly Spindle Stabilization RNA Biosynthetic Process Cellular Response To Interferon-gamma Chromatin Assembly Or Disassembly Leukocyte Activation Involved In Immune Response Neuron Projection Morphogenesis Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway T-helper 17 Cell Lineage Commitment	Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cell Activation Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Gene Expression Positive Regulation Of B Cell Activation Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Lymphocyte Activation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Activation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Cellular Nitrogen Compound Metabolic Process Cell Fate Commitment Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Developmental Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of B Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription T-helper Cell Lineage Commitment Negative Regulation Of RNA Biosynthetic Process Immune System Process Type 2 Immune Response Epithelial Cell Development CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Organ Development Lymphocyte Differentiation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Immune Response
Tagcloud ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk1 tlks tousled yielded	ablation abolish adhesions attenuate chip cistrome compromise decidual decidualization decidualized deep focal forkhead foxo1 hesc igfbp1 integrating intervals o1a occupancy ontology overlap pka pr prl seq shared transcriptome wnt4
Tagcloud (Difference) ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk1 tlks tousled yielded	ablation abolish adhesions attenuate chip cistrome compromise decidual decidualization decidualized deep focal forkhead foxo1 hesc igfbp1 integrating intervals o1a occupancy ontology overlap pka pr prl seq shared transcriptome wnt4
Tagcloud (Intersection) ?