TLK2 and ASF1B

Number of citations of the paper that reports this interaction (PMID 11470414)
52

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TLK2	ASF1B
Gene Name		tousled-like kinase 2	anti-silencing function 1B histone chaperone
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm	Nuclear Chromatin Nucleoplasm Protein Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Histone Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Chromatin Modification Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation	DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Chromatin Modification Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ASF1A ASF1B AURKA FEZ1 FEZ2 IRF4 IRF7 MBP TLK1 YWHAZ	14 interactors: ASF1A C15orf41 CHAF1A CHAF1B H3F3A HCFC1 HIRA HIST1H3C HIST1H3E HIST1H4F HIST4H4 TAF1 TLK1 TLK2
Entrez ID		11011	55723
HPRD ID		10527	16460
Ensembl ID			ENSG00000105011
Uniprot IDs		Q86UE8	Q9NVP2
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization DNA Replication-dependent Nucleosome Assembly Chromosome Organization Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-4 Production DNA Replication-independent Nucleosome Assembly Cell Differentiation Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cell Differentiation Positive Regulation Of Cytokine Production Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of Spindle Checkpoint Positive Regulation Of Interleukin-13 Biosynthetic Process Response To External Stimulus Organelle Localization Regulation Of Cellular Component Organization Organelle Organization Spindle Assembly Involved In Female Meiosis I Positive Regulation Of Interleukin-10 Biosynthetic Process MDA-5 Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Cellular Process Response To Stress Nucleosome Assembly Gene Expression Interferon-gamma-mediated Signaling Pathway Regulation Of Cytokine Production Spindle Assembly Involved In Meiosis Defense Response To Nematode Interferon-beta Production Immune Response Transcription, DNA-templated Chromatin Assembly Defense Response Nucleosome Organization Interferon-alpha Production Negative Regulation Of Macrophage Apoptotic Process Golgi Reassembly Spindle Stabilization RNA Biosynthetic Process Cellular Response To Interferon-gamma Chromatin Assembly Or Disassembly Leukocyte Activation Involved In Immune Response Neuron Projection Morphogenesis Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway T-helper 17 Cell Lineage Commitment	DNA Replication-dependent Nucleosome Assembly Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Chromosome Organization Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly DNA Packaging DNA Conformation Change DNA Methylation On Cytosine Cellular Macromolecular Complex Assembly Chromatin Silencing At RDNA Organelle Organization DNA Replication-independent Nucleosome Assembly Chromatin Silencing DNA Methylation Chromatin Modification Protein Complex Assembly Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Cellular Component Assembly DNA Metabolic Process Gene Expression Cell Cycle Regulation Of Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H4-K20 Demethylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Regulation Of Chromatin Assembly Or Disassembly Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Stress
Tagcloud ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk1 tlks tousled yielded	aid avenue caf cenp centromeric chaperones clustering dataset decisions discriminate distinguish exploit guide hierarchical hjurp implicating ki67 luminal offers outperforming p150 p60 regulators substratification tools transcriptome unfavorable unsupervised utilized
Tagcloud (Difference) ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk1 tlks tousled yielded	aid avenue caf cenp centromeric chaperones clustering dataset decisions discriminate distinguish exploit guide hierarchical hjurp implicating ki67 luminal offers outperforming p150 p60 regulators substratification tools transcriptome unfavorable unsupervised utilized
Tagcloud (Intersection) ?