TLK2 and ASF1B

Number of citations of the paper that reports this interaction (PubMedID 11470414)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TLK2	ASF1B
Description		tousled like kinase 2	anti-silencing function 1B histone chaperone
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Intermediate Filament Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity	Protein Binding Histone Binding Histone Chaperone Activity
	Biological Process	Chromatin Organization Protein Phosphorylation DNA Damage Response Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Nucleus Localization Cellular Response To Gamma Radiation Regulation Of Chromatin Organization	Blastocyst Hatching Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Spermatogenesis Cell Differentiation
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lifespan ( 25918517) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ	13 interacting genes: ASF1A CDIN1 CHAF1A CHAF1B H3-3A H3C3 H3C6 H4C16 H4C6 HCFC1 TAF1 TLK1 TLK2
Entrez ID		11011	55723
HPRD ID		10527	16460
Ensembl ID		ENSG00000146872	ENSG00000105011
Uniprot IDs		A0A804HJZ9 A0A804HK10 B4DUC2 J3QLK5 Q86UE8	Q9NVP2
PDB IDs		5O0Y 7LO0	5BNX 5BO0 7V1M 7VCQ
Enriched GO Terms of Interacting Partners?		Chromatin Organization DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Regulation Of Vacuole Organization Negative Regulation Of Autophagosome Assembly Histone Chaperone Activity Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Toll-like Receptor Signaling Pathway Chromatin Positive Regulation Of Metalloendopeptidase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding SUMO Conjugating Enzyme Activity Negative Regulation Of Macroautophagy Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Gamma-tubulin Binding Nucleus Regulation Of Autophagosome Assembly	Nucleosome Assembly Protein-DNA Complex Assembly Chromatin Organization Nucleosome Organization Chromatin Remodeling Protein-containing Complex Structural Constituent Of Chromatin DNA Replication-dependent Chromatin Assembly Nucleosome Telomere Organization Protein-containing Complex Assembly Chromosome Organization Protein Heterodimerization Activity Protein-containing Complex Organization Nucleus Nucleoplasm CAF-1 Complex Chromosome Protein Localization To Chromatin Cellular Component Assembly DNA Damage Response Protein Localization To Chromosome CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Chromatin RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Chromatin Organization MLL1 Complex Chromosome, Telomeric Region Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Chromatin Binding DNA Binding Positive Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Stress Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Protein Autoubiquitination Cadherin Binding Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Phosphorylation Protein Serine Kinase Activity Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Chromosome Condensation Acetyl-CoA Binding Phosphorylation Muscle Cell Differentiation Pericentric Heterochromatin Formation Release From Viral Latency
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