TLK2 and AURKA

Number of citations of the paper that reports this interaction (PMID 17940067)
19

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		TLK2	AURKA
Gene Name		tousled-like kinase 2	aurora kinase A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm	Condensed Nuclear Chromosome, Centromeric Region Nucleus Centrosome Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Spindle Pole Centrosome Chromosome Passenger Complex Germinal Vesicle Axon Hillock Pronucleus Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle Meiotic Spindle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Serine Kinase Activity
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Chromatin Modification Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Mitotic Nuclear Division Mitotic Centrosome Separation Anterior/posterior Axis Specification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Histone-serine Phosphorylation Negative Regulation Of Apoptotic Process Spindle Stabilization Positive Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Cycle Protein Autophosphorylation Cell Division Centrosome Localization Protein Localization To Centrosome Negative Regulation Of Spindle Checkpoint Positive Regulation Of Oocyte Maturation Neuron Projection Extension
Pathways			APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of mitotic cell cycle G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic
Drugs			Phosphonothreonine Adenosine-5\'-Diphosphate 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4\',3\':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea 1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide 2-(1H-pyrazol-3-yl)-1H-benzimidazole N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ASF1A ASF1B AURKA FEZ1 FEZ2 IRF4 IRF7 MBP TLK1 YWHAZ	54 interactors: APP ARPC1B ARPC2 AURKAIP1 BIRC5 BORA BRCA1 CBX3 CDC20 CDC25B CHFR CKAP5 CSN2 GADD45A GMNN GSK3B HDAC2 HDAC6 HIST3H3 IKBKB INCENP KIF11 KIF2C MAPRE2 MAPRE3 MBD3 MDM2 NDC80 NFKBIA NIN NME1 NUF2 PLK3 PML PPP1CA PPP1CB PPP1CC PRKACA PTTG1 PUM2 RASSF1 SRPK1 SRPK2 SUMO1 TACC1 TACC3 TLK1 TLK2 TP53 TP73 TPX2 UBE2N USP2 VHL
Entrez ID		11011	6790
HPRD ID		10527	04066
Ensembl ID			ENSG00000087586
Uniprot IDs		Q86UE8	O14965
PDB IDs			1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 4B0G 4DEA 4DEB 4DED 4DEE 4DHF 4JAI 4JAJ 4JBO 4JBP 4JBQ
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization DNA Replication-dependent Nucleosome Assembly Chromosome Organization Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-4 Production DNA Replication-independent Nucleosome Assembly Cell Differentiation Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cell Differentiation Positive Regulation Of Cytokine Production Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of Spindle Checkpoint Positive Regulation Of Interleukin-13 Biosynthetic Process Response To External Stimulus Organelle Localization Regulation Of Cellular Component Organization Organelle Organization Spindle Assembly Involved In Female Meiosis I Positive Regulation Of Interleukin-10 Biosynthetic Process MDA-5 Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Cellular Process Response To Stress Nucleosome Assembly Gene Expression Interferon-gamma-mediated Signaling Pathway Regulation Of Cytokine Production Spindle Assembly Involved In Meiosis Defense Response To Nematode Interferon-beta Production Immune Response Transcription, DNA-templated Chromatin Assembly Defense Response Nucleosome Organization Interferon-alpha Production Negative Regulation Of Macrophage Apoptotic Process Golgi Reassembly Spindle Stabilization RNA Biosynthetic Process Cellular Response To Interferon-gamma Chromatin Assembly Or Disassembly Leukocyte Activation Involved In Immune Response Neuron Projection Morphogenesis Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway T-helper 17 Cell Lineage Commitment	Cell Cycle Organelle Organization Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Cell Cycle Cell Division Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Radiation Entrainment Of Circadian Clock By Photoperiod Regulation Of Organelle Organization Regulation Of Proteolysis Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Cellular Protein Modification Process Chromosome Segregation Negative Regulation Of Biosynthetic Process Response To Stress Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Cell Cycle Checkpoint Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Regulation Of Cell Death Response To Light Stimulus Cellular Protein Metabolic Process Circadian Rhythm Response To Growth Factor Regulation Of Apoptotic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Negative Regulation Of Catalytic Activity Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Cellular Component Organization
Tagcloud ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk1 tlks tousled yielded	adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing killing kip1 mitochondria monophosphate n78 nci orally phosphatidylinositol proapoptotic proautophagic responds sb202191 threonine waf1 wortmannin
Tagcloud (Difference) ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal tlk1 tlks tousled yielded	adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing killing kip1 mitochondria monophosphate n78 nci orally phosphatidylinositol proapoptotic proautophagic responds sb202191 waf1 wortmannin
Tagcloud (Intersection) ?		threonine