TLK2 and MBP

Number of citations of the paper that reports this interaction (PMID 10523312)
32

Data Source:
HPRD (in vitro)

		TLK2	MBP
Gene Name		tousled-like kinase 2	myelin basic protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm	Nucleus Plasma Membrane Internode Region Of Axon Neuronal Cell Body Compact Myelin
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protease Binding Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Chromatin Modification Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation	Immune Response Synaptic Transmission Central Nervous System Development Aging Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Response To Progesterone Response To Tumor Necrosis Factor Myelination Response To Mercury Ion Negative Regulation Of Axonogenesis Membrane Organization Response To Fatty Acid
Pathways
Drugs
Diseases
GWAS			Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		10 interactors: ASF1A ASF1B AURKA FEZ1 FEZ2 IRF4 IRF7 MBP TLK1 YWHAZ	72 interactors: ABL1 APTX ATN1 ATXN1 BMP2K CCNC CCNH CCNT1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPKAPK5 MELK MICU2 MKNK1 MMP7 MNAT1 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1
Entrez ID		11011	4155
HPRD ID		10527	01158
Ensembl ID			ENSG00000197971
Uniprot IDs		Q86UE8	P02686
PDB IDs			1BX2 1FV1 1HQR 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization DNA Replication-dependent Nucleosome Assembly Chromosome Organization Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-4 Production DNA Replication-independent Nucleosome Assembly Cell Differentiation Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cell Differentiation Positive Regulation Of Cytokine Production Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of Spindle Checkpoint Positive Regulation Of Interleukin-13 Biosynthetic Process Response To External Stimulus Organelle Localization Regulation Of Cellular Component Organization Organelle Organization Spindle Assembly Involved In Female Meiosis I Positive Regulation Of Interleukin-10 Biosynthetic Process MDA-5 Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Cellular Process Response To Stress Nucleosome Assembly Gene Expression Interferon-gamma-mediated Signaling Pathway Regulation Of Cytokine Production Spindle Assembly Involved In Meiosis Defense Response To Nematode Interferon-beta Production Immune Response Transcription, DNA-templated Chromatin Assembly Defense Response Nucleosome Organization Interferon-alpha Production Negative Regulation Of Macrophage Apoptotic Process Golgi Reassembly Spindle Stabilization RNA Biosynthetic Process Cellular Response To Interferon-gamma Chromatin Assembly Or Disassembly Leukocyte Activation Involved In Immune Response Neuron Projection Morphogenesis Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway T-helper 17 Cell Lineage Commitment	Protein Phosphorylation Phosphorylation Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Signal Transduction By Phosphorylation Protein Autophosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Protein Kinase Activity Peptidyl-threonine Phosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway MAPK Cascade Cellular Response To Stress Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Response To Stimulus Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Death Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus Regulation Of MAP Kinase Activity Apoptotic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process
Tagcloud ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk1 tlks tousled yielded	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Difference) ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk1 tlks tousled yielded	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Intersection) ?