COPS5 and USP14

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		COPS5	USP14
Gene Name		COP9 signalosome subunit 5	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm	Proteasome Complex Nucleus Cytoplasm Plasma Membrane Cell Surface Cytoplasmic Membrane-bounded Vesicle Synapse Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding TRNA Guanylyltransferase Activity Proteasome Binding
	Biological Process	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion	Synaptic Transmission Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	7 interactors: COPS5 CXCR4 FANCC UBC USP15 USP21 USP28
Entrez ID		10987	9097
HPRD ID		06888	06279
Ensembl ID		ENSG00000121022	ENSG00000101557
Uniprot IDs		Q92905	B7Z4N8 P54578
PDB IDs		4F7O	2AYN 2AYO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process	Protein Deubiquitination Protein Modification By Small Protein Removal Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone Deubiquitination Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Proteolysis Cellular Macromolecule Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction By P53 Class Mediator DNA Repair Regulation Of MAPK Cascade Histone H2B Conserved C-terminal Lysine Deubiquitination Activation Of MAPK Activity Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Modification Process DNA Damage Checkpoint Catabolic Process Exosomal Secretion Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Viral Life Cycle Response To Transforming Growth Factor Beta Cellular Response To DNA Damage Stimulus Positive Regulation Of MAP Kinase Activity Cell Cycle Checkpoint Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Germ Cell Development Programmed Cell Death Cullin Deneddylation Cell Death Death Activation Of Protein Kinase Activity Monoubiquitinated Protein Deubiquitination DNA Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Abiotic Stimulus
Tagcloud ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	20s abstaining accumulated affecting antagonizes apigenin biochemistry bortezomib chymotrypsin depolarization desired deubiquitinase e6ap fda flavonoid mechanistically pc preferentially proteasomal proteasome psma5 psmb1 psmb2 psmb5 selectively subtle trihydroxyflavone trypsin ubiquitinated
Tagcloud (Difference) ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	20s abstaining accumulated affecting antagonizes apigenin biochemistry bortezomib chymotrypsin depolarization desired deubiquitinase e6ap fda flavonoid mechanistically pc preferentially proteasomal proteasome psma5 psmb1 psmb2 psmb5 selectively subtle trihydroxyflavone trypsin ubiquitinated
Tagcloud (Intersection) ?