USP14 and USP21

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		USP14	USP21
Description		ubiquitin specific peptidase 14	ubiquitin specific peptidase 21
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Synapse Extracellular Exosome Glutamatergic Synapse Presynaptic Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Proteasome Binding Deubiquitinase Activity	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Metal Ion Binding
	Biological Process	Immune System Process Proteolysis Inflammatory Response Chemical Synaptic Transmission Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Chromatin Organization Proteolysis Protein Deubiquitination Ribosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Rescue Of Stalled Ribosome
Pathways		Ub-specific processing proteases Regulation of NF-kappa B signaling	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		19 interacting genes: ATF2 CDK1 CEBPA CXCR4 FANCC ISG15 OGT PSMD2 SEM1 SGTA SPAG5-AS1 TAFAZZIN TGFBR1 TRIM11 UBC USP15 USP21 USP28 XRCC6	65 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXD1 FOXM1 H2AC18 H2BC3 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RIPK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 YY1 ZNF350
Entrez ID		9097	27005
HPRD ID		06279	05291
Ensembl ID		ENSG00000101557	ENSG00000143258
Uniprot IDs		P54578	Q9UK80
PDB IDs		2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?		Nucleoplasm Macromolecule Metabolic Process Protein Metabolic Process Protein Modification Process Response To Stress Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Post-translational Protein Modification Nucleus Regulation Of Multicellular Organismal Development Protein-containing Complex Protein Tag Activity Cysteine-type Deubiquitinase Activity Cellular Response To Stress DNA Damage Response White Fat Cell Differentiation DNA Damage Checkpoint Signaling Cellular Response To Chemical Stress DNA Repair Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Peptidyl-threonine Phosphorylation Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Deubiquitinase Activity Cysteine-type Peptidase Activity Regulation Of Developmental Process Negative Regulation Of Cell Cycle Cyclin Binding Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Response To Virus DNA Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Pronuclear Fusion Regulation Of Cell Differentiation Positive Regulation Of Biosynthetic Process Cell Population Proliferation Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Abducens Nucleus Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway	Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification Process Protein Deubiquitination Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Proteolysis Protein Metabolic Process Peptidase Activity Macromolecule Metabolic Process Protein K48-linked Deubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Deubiquitinase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity Ubiquitin Protein Ligase Activity Protein K63-linked Deubiquitination Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Catabolic Process K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Polyubiquitination Hydrolase Activity Ubiquitin Protein Ligase Binding Monoubiquitinated Protein Deubiquitination Regulation Of Cellular Response To Stress Ubiquitin Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process TOR Signaling Response To Stress Nucleoplasm DeNEDDylase Activity DNA Damage Response Zinc Ion Binding Negative Regulation Of TOR Signaling Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction DNA Repair Regulation Of Telomere Maintenance Positive Regulation Of Autophagy Negative Regulation Of Intracellular Signal Transduction
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