BCL3 and GSK3B

Number of citations of the paper that reports this interaction (PMID 15469820)
33

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)
HPRD (in vivo, in vitro)

		BCL3	GSK3B
Gene Name		B-cell CLL/lymphoma 3	glycogen synthase kinase 3 beta
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Protein Complex Intercellular Bridge Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Growth Cone Ribonucleoprotein Complex Beta-catenin Destruction Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Binding, Bridging	RNA Polymerase II Transcription Factor Binding P53 Binding Protein Serine/threonine Kinase Activity Integrin Binding Protein Binding ATP Binding Beta-catenin Binding Kinase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding Ionotropic Glutamate Receptor Binding Tau Protein Binding Tau-protein Kinase Activity NF-kappaB Binding
	Biological Process	Protein Import Into Nucleus, Translocation Follicular Dendritic Cell Differentiation Marginal Zone B Cell Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Germinal Center Formation Transcription, DNA-templated Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Response To Virus Response To UV-C Antimicrobial Humoral Response Extracellular Matrix Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Interferon-gamma Production T-helper 1 Type Immune Response Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Defense Response To Protozoan Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process T-helper 2 Cell Differentiation Positive Regulation Of Interleukin-10 Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Translation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Regulation Of DNA Binding Maintenance Of Protein Location In Nucleus	Re-entry Into Mitotic Cell Cycle Epithelial To Mesenchymal Transition Positive Regulation Of Cell-matrix Adhesion Glycogen Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Protein Phosphorylation Protein Export From Nucleus ER Overload Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Myoblast Fusion Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Response To Lithium Ion Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Neuron Maturation Cell Migration Peptidyl-serine Phosphorylation Hippocampus Development Establishment Of Cell Polarity Negative Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rac GTPase Activity Regulation Of Microtubule-based Process Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Heat Protein Localization To Microtubule Intracellular Signal Transduction Cellular Response To Interleukin-3 Fc-epsilon Receptor Signaling Pathway Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Innate Immune Response Fat Cell Differentiation Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Axon Extension Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Export From Nucleus Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Canonical Wnt Signaling Pathway Superior Temporal Gyrus Development Cellular Response To Mechanical Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Response To Heat Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Stem Cell Differentiation
Pathways			Signaling by the B Cell Receptor (BCR) Hedgehog 'off' state Signaling by FGFR in disease misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex PI3K/AKT activation PI-3K cascade RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex Signaling by PDGF DAP12 interactions GAB1 signalosome misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer CRMPs in Sema3A signaling Adaptive Immune System Axon guidance PIP3 activates AKT signaling APC truncation mutants have impaired AXIN binding APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated PI3K events in ERBB2 signaling Downstream signaling of activated FGFR XAV939 inhibits tankyrase, stabilizing AXIN Innate Immune System Signalling by NGF Semaphorin interactions Signaling by Ligand-Responsive EGFR Variants in Cancer Regulation of HSF1-mediated heat shock response Cellular response to heat stress NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR TCF dependent signaling in response to WNT Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs			Lithium 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione I-5 N-(4-Methoxybenzyl)-N\'-(5-Nitro-1,3-Thiazol-2-Yl)Urea Staurosporine Indirubin-3\'-Monoxime Adenosine-5\'-Diphosphate (3e)-6\'-Bromo-2,3\'-Biindole-2\',3(1h,1\'h)-Dione 3-Oxime Alsterpaullone Phosphoaminophosphonic Acid-Adenylate Ester 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2\'H-2,3\'-biindol-2\'-one N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
GWAS		Alzheimer's disease (late onset) ( 23565137)
Protein-Protein Interactions		31 interactors: BARD1 COPS5 CREBBP CTBP1 CTBP2 CTNNB1 EP300 FOS FYN GSK3A GSK3B GTF2A1 GTF2B HDAC1 HDAC3 HDAC6 JUN KAT5 MAPK3 MAPRE1 N4BP2 NCOA1 NCOA6 NFKB1 NFKB2 PIR RAB9A RUVBL2 RXRA SHC1 TBP	206 interactors: ACLY ACSBG1 ACTL6B ADAP1 ADIRF AKAP11 AKT1 AKT2 AKT3 APC APP AR ARRB1 ASRGL1 ATPIF1 ATXN3 AURKA AXIN1 AXIN2 BAG6 BCL3 BEX1 BICD1 BICD2 BRIX1 BTRC BZW2 C14orf1 CABYR CAMSAP3 CCND1 CCNE1 CDH1 CDK5 CDX2 CEBPA CEBPZ CENPB CHD3 CIITA CLEC3B CREB1 CREM CSAD CST6 CTNNB1 CTNND1 DBI DCTN1 DCTN2 DCTN3 DDIT4 DEAF1 DEFA1 DHX34 DNAJC13 DNM1L DNMT1 DNMT3L DPYSL2 DUSP9 DYNC1I1 E2F1 EEF1A1 EEF1G EFTUD2 EIF2B5 EIF4EBP1 ENTPD6 EYA1 FAM193B FAM83D FBN3 FEN1 FIBP FKBP14 FOXO1 FRAT1 FRAT2 FZD5 GAPDH GBP2 GIPC1 GJB5 GNB2 GPR39 GYS1 HDAC4 HNRNPD HSP90AA1 HSPA4 IGHM IGSF21 IKBKG ILK IQCG JUN KHSRP KIAA1191 KIF5B KLF2 KLF5 LMO4 LRP6 LUC7L2 MAP1B MAP3K1 MAP3K4 MAP4 MAPK1 MAPT MARK2 MASP1 MCL1 MDM2 MED24 MGEA5 MICAL1 MID1IP1 MITF MPP1 MTF2 MTOR MUC1 MYC MYOCD NAT9 NBR1 NCOA3 NFE2L1 NFE2L2 NFKB1 NIN NOTCH1 NOTCH2 NRBP1 NSFL1C OGT PDE4D PFKFB4 PHLPP1 PIK3R1 PIM2 PMAIP1 PPARGC1A PPP1R2 PRKACA PRKCA PRKCB PRKCZ PRKDC PSEN1 PTK2 PTN PTPN1 PXN QARS RAI1 RBPJ RCAN1 RELB RICTOR RPL36AL RPLP1 RPS2 RPS6KA1 RSU1 RXRA SAP30BP SGK1 SGK3 SLA SMAD1 SMAD3 SNAI1 SNCA SNCAIP SPTBN4 SREBF1 SYNE4 TAZ TLE1 TMEM132A TMEM44 TONSL TP53 TPPP TSC2 TUBA1A UBE2D1 UBR1 UBR5 UBXN6 UFM1 UPF3A VIM VPS51 WSB1 XPNPEP1 YBX1 YBX3 ZFPM1 ZHX1 ZNF135 ZNF227 ZNF746
Entrez ID		602	2932
HPRD ID		00179	05418
Ensembl ID		ENSG00000069399	ENSG00000082701
Uniprot IDs		P20749	P49841 Q6FI27
PDB IDs		1K1A 1K1B	1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW 3DU8 3E87 3E88 3E8D 3F7Z 3F88 3GB2 3I4B 3L1S 3M1S 3PUP 3Q3B 3SAY 3SD0 3ZDI 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B7T 4DIT 4EKK 4IQ6 4J1R 4J71
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Viral Process Response To Growth Factor Response To Organic Substance Cellular Response To Organic Substance Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Hormone Cellular Response To Hormone Stimulus Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway DNA-templated Transcription, Initiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Histone Modification Cellular Response To Stress Fc Receptor Signaling Pathway Regulation Of Protein Metabolic Process	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Gene Expression Response To Stress Cellular Response To Stimulus Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Regulation Of Signal Transduction Apoptotic Process Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Protein Metabolic Process Cell Death Death Programmed Cell Death Regulation Of Cell Differentiation Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Gene Expression Multicellular Organismal Development Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Negative Regulation Of Transcription, DNA-templated Cell Differentiation Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	200mg clamp coagulation confirmation dm downregulated encountered f3 gskbeta3 hg hi hour hyperglycemia hyperinsulinemia ingenuity monocyte monocytes pik3c3 platelet platelets proinflammatory prothrombotic ptpn1 ptpn11 qrt stxbp4 tf tfpi thrombin
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses rca1 xpq xq25	200mg clamp coagulation confirmation dm downregulated encountered f3 gskbeta3 hg hi hour hyperglycemia hyperinsulinemia ingenuity monocyte monocytes pik3c3 platelet platelets proinflammatory prothrombotic ptpn11 qrt stxbp4 tf tfpi thrombin
Tagcloud (Intersection) ?		ptpn1