BCL3 and PIR

Number of citations of the paper that reports this interaction (PubMedID 10362352)
0

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		BCL3	PIR
Description		BCL3 transcription coactivator	pirin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Midbody Protein-containing Complex Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein-macromolecule Adaptor Activity Histone Deacetylase Binding DNA-binding Transcription Factor Binding	Transcription Coregulator Activity Protein Binding Quercetin 2,3-dioxygenase Activity Oxidoreductase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Cytokine Production Follicular Dendritic Cell Differentiation Marginal Zone B Cell Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Germinal Center Formation Protein Import Into Nucleus Apoptotic Process Response To Stress DNA Damage Response Canonical NF-kappaB Signal Transduction Response To Virus Response To UV-C Positive Regulation Of Gene Expression Antimicrobial Humoral Response Extracellular Matrix Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production T-helper 1 Type Immune Response Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Defense Response To Protozoan Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process T-helper 2 Cell Differentiation Positive Regulation Of Translation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Spleen Development Regulation Of DNA Binding Response To Other Organism T Cell Apoptotic Process Negative Regulation Of T Cell Apoptotic Process Regulation Of Non-canonical NF-kappaB Signal Transduction	Transcription By RNA Polymerase II Digestion Myeloid Cell Differentiation Monocyte Differentiation
Pathways			Digestion
Drugs
Diseases
GWAS		Alzheimer's disease ( 24755620 30636644) Alzheimer's disease (late onset) ( 23565137) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Asthma ( 32296059) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		35 interacting genes: AKT1 ANKRD28 BARD1 CHUK COPS5 CREBBP CTBP1 CTBP2 CTNNB1 EP300 FOS FYN GSK3A GSK3B GTF2A1 GTF2B HDAC1 HDAC3 HDAC6 JUN KAT5 MAPK1 MAPK3 MAPRE1 N4BP2 NCOA1 NFKB1 NFKB2 PIR RAB9A RUVBL2 RXRA SHC1 TBP TRAF6	4 interacting genes: BCL3 NFIX NFKBIA SMAD9
Entrez ID		602	8544
HPRD ID		00179	04510
Ensembl ID		ENSG00000069399	ENSG00000087842
Uniprot IDs		B7Z3N9 P20749	O00625
PDB IDs		1K1A 1K1B	1J1L 3ACL 4ERO 4EWA 4EWD 4EWE 4GUL 4HLT 5JCT 6H1H 6H1I 6N0J 6N0K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Response To Lipid Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Intracellular Signal Transduction Regulation Of Gene Expression Nucleoplasm RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Transcription By RNA Polymerase II Cytosol Enzyme Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Chromatin Binding Nucleus Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Tau Protein Binding Regulation Of Apoptotic Process Transcription Corepressor Binding Macromolecule Biosynthetic Process Macromolecule Metabolic Process	Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Bcl3-Bcl10 Complex Protein Import Into Nucleus Import Into Nucleus Bcl3/NF-kappaB2 Complex Intracellular Signaling Cassette Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Follicular Dendritic Cell Differentiation Positive Regulation Of Biosynthetic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Nucleus Follicular Dendritic Cell Activation I-kappaB/NF-kappaB Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of RNA Biosynthetic Process Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process SMAD Protein Complex Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Heteromeric SMAD Protein Complex Germinal Center Formation Regulation Of Nucleobase-containing Compound Metabolic Process T-helper 2 Cell Differentiation Negative Regulation Of RNA Metabolic Process Marginal Zone B Cell Differentiation Negative Regulation Of Cytokine Production T-helper 1 Type Immune Response Establishment Of Protein Localization To Organelle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Response To UV-C Cellular Response To Cold I-SMAD Binding Intracellular Signal Transduction Negative Regulation Of Protein Import Into Nucleus
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