PLAC8 and LCE1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLAC8	LCE1A
Description		placenta associated 8	late cornified envelope 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Azurophil Granule Lumen	Cytosol
	Molecular Function	Chromatin Binding	Protein Binding
	Biological Process	Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Response To Cold Negative Regulation Of Multicellular Organism Growth Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis	Epidermis Development Keratinization
Pathways		Neutrophil degranulation Formation of the nephric duct	Formation of the cornified envelope
Drugs
Diseases
GWAS		QRS interval (sulfonylurea treatment interaction) ( 27958378)	Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		24 interacting genes: ACTMAP BAG4 COPS5 CYSRT1 FCHO1 KRTAP12-2 KRTAP19-1 KRTAP19-6 LCE1A LCE1C LCE2B LCE5A MEOX2 PLAGL2 PPP3CA RBPMS RHOXF2 SPMIP9 TRAF1 TRIP13 UBAP2 USP54 VAMP5 WWOX	83 interacting genes: ADAMTSL4 AQP1 CCN3 CFP CHIC2 CRCT1 CYSRT1 EFEMP2 FBLN1 FUCA2 GRN HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A LCE5A MACO1 MDFI MESD NBPF19 NID2 NOTCH2NLA PLA2G10 PLAC8 PLSCR2 PLSCR4 RGS17 RGS20 SLC39A7 SMCP SPRY1 SPRY2 SPRY3 TGFB1 TRIM42 TSPAN4 VASN VWC2 VWC2L
Entrez ID		51316	353131
HPRD ID		06335	13966
Ensembl ID		ENSG00000145287	ENSG00000186844
Uniprot IDs		Q9NZF1 X2BQ60	Q5T7P2
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermis Development Keratinization Tissue Development	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Protein Binding Identical Protein Binding Branch Elongation Of An Epithelium Axis Elongation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Elastic Fiber Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Lens Fiber Cell Differentiation
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