ERP29 and TMBIM6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ERP29	TMBIM6
Description		endoplasmic reticulum protein 29	transmembrane BAX inhibitor motif containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cell Surface Membrane Melanosome	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Protein Homodimerization Activity Protein-folding Chaperone Binding	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity
	Biological Process	Protein Folding Intracellular Protein Transport Protein Secretion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Unfolding Positive Regulation Of MAPK Cascade Negative Regulation Of Protein Secretion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	General cognitive ability ( 29844566)
Interacting Genes		21 interacting genes: ADIPOQ BMP10 C3orf52 CEBPA CTNNBL1 DESI1 GLP1R HMG20B HSPA5 NRM PUF60 SGTA SGTB SLC35B4 SLC38A7 TMBIM6 TMEM86B TSPO2 UBQLN1 UBQLN2 UBQLN4	66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A
Entrez ID		10961	7009
HPRD ID		03794	02851
Ensembl ID		ENSG00000089248	ENSG00000139644
Uniprot IDs		P30040 V9HW71	P55061
PDB IDs		2QC7 5V8Z 5V90
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis ERAD Pathway Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Membrane, Translocation Regulation Of Cellular Response To Stress Regulation Of Protein Metabolic Process Endoplasmic Reticulum Regulation Of Ubiquitin-dependent Protein Catabolic Process IRE1-mediated Unfolded Protein Response Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Autophagosome Regulation Of IRE1-mediated Unfolded Protein Response Protein-containing Complex Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Positive Regulation Of Protein Metabolic Process Autophagy Brown Fat Cell Differentiation Protein Targeting To ER Intracellular Protein Transmembrane Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Establishment Of Protein Localization To Endoplasmic Reticulum RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Integrated Stress Response Signaling Glucagon-like Peptide 1 Receptor Activity Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Store-operated Calcium Channel Activity	Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport
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