DBF4 and CHEK2

Number of citations of the paper that reports this interaction (PMID 12441400)
37

Data Source:
HPRD (two hybrid, in vivo)

		DBF4	CHEK2
Gene Name		DBF4 zinc finger	checkpoint kinase 2
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Gene Ontology Annotations	Cellular Component	Nucleoplasm	Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus PML Body
	Molecular Function	Nucleic Acid Binding Enzyme Activator Activity Zinc Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Positive Regulation Of Catalytic Activity	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence
Pathways		G1/S Transition G2/M Checkpoints Activation of ATR in response to replication stress Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Cell Cycle Checkpoints Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Breast cancer ( 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		17 interactors: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MEN1 ORC1 ORC2 ORC3 ORC5 ORC6	47 interactors: AATF APP ARHGAP1 ASF1A ATM ATR BRCA1 BRCA2 CDC25A CDC25C DAPK3 DBF4 E2F1 ELAVL1 ERCC6 FOXM1 KPNA2 LATS2 MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 PLK1 PLK3 POLR2L PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RAD9A RCHY1 REV3L RNF8 SRPK1 STRAP TP53 TSSK1B VHL
Entrez ID		10926	11200
HPRD ID		10371	05084
Ensembl ID		ENSG00000006634	ENSG00000183765
Uniprot IDs		B7Z8C6 Q9UBU7	O96017
PDB IDs		4F99 4F9A 4F9B 4F9C	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nitrogen Compound Metabolic Process DNA Unwinding Involved In DNA Replication Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change DNA Conformation Change Cellular Response To DNA Damage Stimulus Chromosome Organization Cellular Metabolic Process Regulation Of DNA Replication DNA Repair Cellular Response To Stress Organelle Organization Regulation Of Nuclear Cell Cycle DNA Replication Signal Transduction In Response To DNA Damage Positive Regulation Of DNA-dependent DNA Replication Metabolic Process Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Response To Epidermal Growth Factor Stimulus DNA Damage Checkpoint Response To Epidermal Growth Factor Negative Regulation Of Cell Cycle Positive Regulation Of Histone Methylation Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Process Negative Regulation Of DNA Replication Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition	Cellular Response To DNA Damage Stimulus Cell Cycle Process Cellular Response To Stress Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Process DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Checkpoint Response To Stress Signal Transduction By P53 Class Mediator DNA Repair Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Response To Stimulus Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Negative Regulation Of Cell Cycle Apoptotic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Programmed Cell Death Mitotic DNA Damage Checkpoint Regulation Of Protein Metabolic Process Double-strand Break Repair Mitotic DNA Integrity Checkpoint Cell Death Death Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Response To Abiotic Stimulus Signal Transduction DNA Recombination Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Signaling Nucleobase-containing Compound Metabolic Process Cell Communication Double-strand Break Repair Via Homologous Recombination Recombinational Repair
Tagcloud ?		bud cdc28 cdc4 cdc7 cln1 cln2 cln3 commited conceivable cyclins dsc1 duplication else firstly hartley hfs1 jackson mcb p34cdc28 pole principally redundancy rosamond sbf scb scm4 smith swi6 unpublished	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		bud cdc28 cdc4 cdc7 cln1 cln2 cln3 commited conceivable cyclins dsc1 duplication else firstly hartley hfs1 jackson mcb p34cdc28 pole principally redundancy rosamond sbf scb scm4 smith swi6 unpublished	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?