DBF4 and ORC2

Number of citations of the paper that reports this interaction (PMID 12441400)
37

Data Source:
HPRD (in vitro, two hybrid)

		DBF4	ORC2
Gene Name		DBF4 zinc finger	origin recognition complex, subunit 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Plasma Membrane Membrane
	Molecular Function	Nucleic Acid Binding Enzyme Activator Activity Zinc Ion Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Positive Regulation Of Catalytic Activity	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		G1/S Transition G2/M Checkpoints Activation of ATR in response to replication stress Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Cell Cycle Checkpoints Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic	G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MEN1 ORC1 ORC2 ORC3 ORC5 ORC6	24 interactors: CDC45 CDC5L CDC6 CDK2 CDT1 DBF4 HIST3H3 HIST4H4 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RPA1 RPA2 XRCC5
Entrez ID		10926	4999
HPRD ID		10371	03112
Ensembl ID		ENSG00000006634
Uniprot IDs		B7Z8C6 Q9UBU7	Q13416
PDB IDs		4F99 4F9A 4F9B 4F9C
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nitrogen Compound Metabolic Process DNA Unwinding Involved In DNA Replication Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change DNA Conformation Change Cellular Response To DNA Damage Stimulus Chromosome Organization Cellular Metabolic Process Regulation Of DNA Replication DNA Repair Cellular Response To Stress Organelle Organization Regulation Of Nuclear Cell Cycle DNA Replication Signal Transduction In Response To DNA Damage Positive Regulation Of DNA-dependent DNA Replication Metabolic Process Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Response To Epidermal Growth Factor Stimulus DNA Damage Checkpoint Response To Epidermal Growth Factor Negative Regulation Of Cell Cycle Positive Regulation Of Histone Methylation Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Process Negative Regulation Of DNA Replication Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition	G1/S Transition Of Mitotic Cell Cycle DNA Replication Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process Mitotic Cell Cycle DNA-dependent DNA Replication Mitotic Cell Cycle Process DNA Replication Initiation Cell Cycle Process Cell Cycle DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process DNA Duplex Unwinding DNA Geometric Change Chromosome Organization Biosynthetic Process DNA Conformation Change DNA Unwinding Involved In DNA Replication Cellular Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance Organelle Organization Cell Cycle Checkpoint DNA Replication Checkpoint Protein-DNA Complex Assembly Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process DNA Recombinase Assembly Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Double-strand Break Repair DNA Repair Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stress DNA Recombination Nucleotide-excision Repair, DNA Gap Filling
Tagcloud ?		bud cdc28 cdc4 cdc7 cln1 cln2 cln3 commited conceivable cyclins dsc1 duplication else firstly hartley hfs1 jackson mcb p34cdc28 pole principally redundancy rosamond sbf scb scm4 smith swi6 unpublished	brdu budding catalytic comprising discs dpolepsilon dpolepsilonp255 dpolepsilonp58 drosophila endoreplication epsilon eye hetero homozygous imaginal instar kda larvae lethal multicellular organism ph3 polepsilon pupal replicating salivary stop strand tetrameric
Tagcloud (Difference) ?		bud cdc28 cdc4 cdc7 cln1 cln2 cln3 commited conceivable cyclins dsc1 duplication else firstly hartley hfs1 jackson mcb p34cdc28 pole principally redundancy rosamond sbf scb scm4 smith swi6 unpublished	brdu budding catalytic comprising discs dpolepsilon dpolepsilonp255 dpolepsilonp58 drosophila endoreplication epsilon eye hetero homozygous imaginal instar kda larvae lethal multicellular organism ph3 polepsilon pupal replicating salivary stop strand tetrameric
Tagcloud (Intersection) ?