DBF4 and LSM8

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DBF4	LSM8
Description		DBF4-CDC7 kinase regulatory subunit	LSM8 homolog, U6 small nuclear RNA associated
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding	RNA Binding MRNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Phase Transition	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935 33627673) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking initiation ( 33082346) Smoking status (current vs never) ( 33082346) Triglyceride levels ( 30108155)
Interacting Genes		19 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK1 CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6	49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1
Entrez ID		10926	51691
HPRD ID		10371	06288
Ensembl ID		ENSG00000006634	ENSG00000128534
Uniprot IDs		B4DXK0 B7Z8C6 Q9UBU7	A4D0W0 O95777
PDB IDs		4F99 4F9A 4F9B 4F9C 6YA6 6YA7 6YA8	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process Chromosome, Telomeric Region Nucleic Acid Metabolic Process Nuclear Origin Of Replication Recognition Complex Nucleobase-containing Compound Metabolic Process MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Replication Origin Recognition Complex Regulation Of DNA-templated DNA Replication Initiation DNA Repair CMG Complex Regulation Of DNA Metabolic Process DNA Damage Response DNA Replication Origin Binding Macromolecule Metabolic Process Nucleoplasm Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Single-stranded DNA Helicase Activity DNA Recombination Mitotic DNA Replication Initiation Nucleus Cellular Response To Stress Mitotic DNA Integrity Checkpoint Signaling Chromosome ATP Binding DNA Helicase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Single-stranded DNA Binding Regulation Of Cell Cycle G2/M Phase Transition Helicase Activity Nucleotide Binding DNA Strand Elongation Involved In DNA Replication Mitotic DNA Damage Checkpoint Signaling DNA Strand Elongation Negative Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process ATP Hydrolysis Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Phase Transition Chromatin Negative Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Response To Stress	U2-type Precatalytic Spliceosome U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions U6 SnRNP MRNA Catabolic Process Spliceosomal Complex Lsm1-7-Pat1 Complex RNA Catabolic Process RNA Splicing Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Processing RNA Processing RNA Binding Ribonucleoprotein Complex Small Nuclear Ribonucleoprotein Complex Precatalytic Spliceosome P-body Nucleobase-containing Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-RNA Complex Assembly Double-stranded DNA Helicase Activity U5 SnRNP Positive Regulation Of MRNA Cis Splicing, Via Spliceosome U12-type Spliceosomal Complex Deadenylation-independent Decapping Of Nuclear-transcribed MRNA U2-type Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex U1 SnRNP Binding Nucleoplasm Poly(A)-dependent SnoRNA 3'-end Processing 7-methylguanosine Cap Hypermethylation Spliceosomal SnRNP Assembly Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Nucleolar Exosome (RNase Complex) 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Nuclear MRNA Surveillance U4 SnRNP Methylosome Macromolecule Metabolic Process Pentose-phosphate Shunt Regulation Of MRNA Processing Septin Ring
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