DBF4 and ORC5

Number of citations of the paper that reports this interaction (PubMedID 12614612)
0

Data Source:
BioGRID (two hybrid)

		DBF4	ORC5
Description		DBF4-CDC7 kinase regulatory subunit	origin recognition complex subunit 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Chromosome Cytosol
	Molecular Function	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Phase Transition	DNA Replication DNA Replication Initiation Regulation Of DNA Replication
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)
Interacting Genes		19 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK1 CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6	31 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 CEBPA DBF4 DMRTA1 H3-4 H4C16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2
Entrez ID		10926	5001
HPRD ID		10371	09086
Ensembl ID		ENSG00000006634	ENSG00000164815
Uniprot IDs		B4DXK0 B7Z8C6 Q9UBU7	A4D0P7 O43913 Q53FC8
PDB IDs		4F99 4F9A 4F9B 4F9C 6YA6 6YA7 6YA8	5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process Chromosome, Telomeric Region Nucleic Acid Metabolic Process Nuclear Origin Of Replication Recognition Complex Nucleobase-containing Compound Metabolic Process MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Replication Origin Recognition Complex Regulation Of DNA-templated DNA Replication Initiation DNA Repair CMG Complex Regulation Of DNA Metabolic Process DNA Damage Response DNA Replication Origin Binding Macromolecule Metabolic Process Nucleoplasm Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Single-stranded DNA Helicase Activity DNA Recombination Mitotic DNA Replication Initiation Nucleus Cellular Response To Stress Mitotic DNA Integrity Checkpoint Signaling Chromosome ATP Binding DNA Helicase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Single-stranded DNA Binding Regulation Of Cell Cycle G2/M Phase Transition Helicase Activity Nucleotide Binding DNA Strand Elongation Involved In DNA Replication Mitotic DNA Damage Checkpoint Signaling DNA Strand Elongation Negative Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process ATP Hydrolysis Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Phase Transition Chromatin Negative Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Response To Stress	DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Nuclear Origin Of Replication Recognition Complex CMG Complex Origin Recognition Complex Regulation Of DNA Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation Nucleic Acid Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Single-stranded DNA Helicase Activity DNA Recombination Regulation Of DNA Metabolic Process DNA Repair Single-stranded DNA Binding Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Chromosome Nucleoplasm Mitotic DNA Replication Initiation DNA Damage Response Nucleus DNA Binding DNA Strand Elongation Involved In DNA Replication DNA Replication Preinitiation Complex Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation Macromolecule Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle DNA Helicase Activity ATP Hydrolysis Activity Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Mitotic DNA Replication Checkpoint Signaling Nucleolus DNA Replication Factor A Complex 3'-5' DNA Helicase Activity Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Process
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