SUGT1 and S100B

Number of citations of the paper that reports this interaction (PMID 12746458)
8

Data Source:
HPRD (in vitro)

		SUGT1	S100B
Gene Name		SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	S100 calcium binding protein B
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Kinetochore Nucleus Cytoplasm Cytosol	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Mitotic Nuclear Division Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs			Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
Diseases
GWAS			Lymphocyte counts ( 22286170)
Protein-Protein Interactions		15 interactors: BUB3 CSNK2A1 DSN1 HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PLK1 PMF1 S100A6 S100B S100P SKP1	27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1
Entrez ID		10910	6285
HPRD ID		09160	01505
Ensembl ID
Uniprot IDs		F5H5A9 Q9Y2Z0	P04271
PDB IDs		1RL1	1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Chromosome Segregation Cell Cycle Mitotic Nuclear Division Cell Division Mitotic Spindle Checkpoint Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chromosome Segregation Organelle Organization Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Endothelial Cell Migration Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Chromosome Organization Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Chaperone-mediated Protein Complex Assembly Epithelial Cell Migration Epithelium Migration Regulation Of Proteolysis Negative Regulation Of Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Proteolysis Regulation Of Mitotic Nuclear Division Negative Regulation Of Protein Processing Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Processing Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Ameboidal-type Cell Migration Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Regulation Of Proteasomal Protein Catabolic Process Axonogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition	Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?			accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Difference) ?			accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Intersection) ?