SUGT1 and PTGER4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SUGT1	PTGER4
Description		SGT1 assembly cochaperone of MIS12 kinetochore complex	prostaglandin E receptor 4
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Kinetochore Nucleus Cytoplasm Cytosol Nuclear Body Protein-containing Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein-folding Chaperone Binding LncRNA Binding	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding
	Biological Process	Spindle Organization Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Kinetochore Assembly	MAPK Cascade Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Negative Regulation Of Integrin Activation Response To Lipid Response To Prostaglandin E T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	Prostanoid ligand receptors G alpha (s) signalling events
Drugs			Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 21743469 23749187) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 26278503 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22570697 21833088 28445677 19525953) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)
Interacting Genes		18 interacting genes: BUB3 CEBPA CSNK2A1 DSN1 FNDC3B HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PLK1 PMF1 PTGER4 S100A6 S100B S100P SKP1	42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337
Entrez ID		10910	5734
HPRD ID		09160	03350
Ensembl ID		ENSG00000165416	ENSG00000171522
Uniprot IDs		A8K7W3 B4DYC6 Q9Y2Z0	A0PJF5 P35408
PDB IDs		1RL1	5YHL 5YWY 7D7M 8GCM 8GCP 8GD9 8GDA 8GDB
Enriched GO Terms of Interacting Partners?		MIS12/MIND Type Complex Outer Kinetochore Attachment Of Spindle Microtubules To Kinetochore Chromosome Segregation Chromosome, Centromeric Region Kinetochore Spindle Pole Protein Localization To Organelle Chromosome Cell Division Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Nuclear Chromosome Segregation Nucleus Negative Regulation Of Cell Cycle Identical Protein Binding Positive Regulation Of Protein Catabolic Process Regulation Of Chromosome Separation Calcium-dependent Protein Binding Endothelial Cell Migration S100 Protein Binding Regulation Of DNA Metabolic Process Nucleoplasm Protein Localization To Chromosome Positive Regulation Of Catabolic Process Chaperone-mediated Protein Complex Assembly Memory Protein Import Into Mitochondrial Matrix Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Hormone Regulation Of DNA Recombination Regulation Of Chromosome Segregation PcG Protein Complex Establishment Of Protein Localization To Organelle Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Chromosome Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Apoptotic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Catabolic Process Regulation Of Programmed Cell Death ATP-dependent Protein Folding Chaperone Regulation Of Cell Cycle Protein Homodimerization Activity Positive Regulation Of Inflammatory Response Protein Localization To Mitochondrion Negative Regulation Of Mitotic Nuclear Division Regulation Of Ubiquitin-dependent Protein Catabolic Process	Heme Oxidation Heme Oxygenase (decyclizing) Activity
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