SUGT1 and BUB3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SUGT1	BUB3
Gene Name		SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	BUB3 mitotic checkpoint protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Kinetochore Nucleus Cytoplasm Cytosol	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Nuclear Division Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Meiotic Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	Mitotic Prometaphase Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components M Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cell Cycle Checkpoints Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: BUB3 CSNK2A1 DSN1 HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PLK1 PMF1 S100A6 S100B S100P SKP1	17 interactors: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 NKAP PARP1 PARP2 PSTPIP1 RPL37A SUGT1 THRA TOP1 UBA1 WBP4 ZNF207
Entrez ID		10910	9184
HPRD ID		09160	04761
Ensembl ID			ENSG00000154473
Uniprot IDs		F5H5A9 Q9Y2Z0	O43684
PDB IDs		1RL1
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Chromosome Segregation Cell Cycle Mitotic Nuclear Division Cell Division Mitotic Spindle Checkpoint Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chromosome Segregation Organelle Organization Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Endothelial Cell Migration Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Chromosome Organization Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Chaperone-mediated Protein Complex Assembly Epithelial Cell Migration Epithelium Migration Regulation Of Proteolysis Negative Regulation Of Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Proteolysis Regulation Of Mitotic Nuclear Division Negative Regulation Of Protein Processing Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Processing Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Ameboidal-type Cell Migration Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Regulation Of Proteasomal Protein Catabolic Process Axonogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition	Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fungiform Papilla Formation Negative Regulation Of Cell Cycle Negative Regulation Of Proteasomal Protein Catabolic Process Fungiform Papilla Morphogenesis Negative Regulation Of Cellular Protein Catabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Fungiform Papilla Development Eyelid Development In Camera-type Eye Negative Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Hair Follicle Placode Formation Tongue Morphogenesis Mitotic Nuclear Division Regulation Of Receptor Biosynthetic Process Negative Regulation Of Protein Catabolic Process Histone H4 Deacetylation Regulation Of Mitotic Nuclear Division Organelle Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein ADP-ribosylation Mitotic Cell Cycle Checkpoint Cell Division Histone H3 Deacetylation Circadian Rhythm Transcription Initiation From RNA Polymerase II Promoter Tongue Development Chromatin Remodeling Histone H3-K9 Modification Regulation Of Proteasomal Protein Catabolic Process Intracellular Receptor Signaling Pathway Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle
Tagcloud ?			abrogates anaphase apc assembles attached bubr1 cdc20 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Difference) ?			abrogates anaphase apc assembles attached bubr1 cdc20 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Intersection) ?