SOCS6 and IRS2

Number of citations of the paper that reports this interaction (PMID 12052866)
26

Data Source:
HPRD (in vitro)

		SOCS6	IRS2
Gene Name		suppressor of cytokine signaling 6	insulin receptor substrate 2
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Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm	Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Signal Transducer Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Defense Response JAK-STAT Cascade Proteasomal Protein Catabolic Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of JAK-STAT Cascade Negative Regulation Of T Cell Activation	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Brain Development Cell Proliferation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Negative Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Lipid Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Glucose Stimulus
Pathways		Signaling by SCF-KIT Regulation of KIT signaling	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		22 interactors: ACVR1 BMPR1B EFEMP1 INSR IRS2 IRS4 KDM1A KIT PIK3R1 PIK3R2 RBCK1 RELA SMURF2 TCEB1 TCEB2 TGFBR1 TUBA1A TUBB4B UBE2D2 UBE2I WDR89 ZMIZ2	38 interactors: ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SIRT1 SOCS1 SOCS3 SOCS6 SOCS7 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ
Entrez ID		9306	8660
HPRD ID		05491	02878
Ensembl ID		ENSG00000170677	ENSG00000185950
Uniprot IDs		O14544	Q9P084 Q9Y4H2
PDB IDs		2VIF	3FQW 3FQX
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Growth Factor Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Cellular Response To Organic Substance Response To Insulin Response To Stimulus Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Viral Process ERBB Signaling Pathway Cellular Protein Modification Process Cellular Response To Stimulus Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Hormone Response To Stress Defense Response Regulation Of Cartilage Development Negative Regulation Of Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Organic Substance Cellular Response To Peptide Response To Peptide Hormone Response To Peptide Response To Organonitrogen Compound Response To Organic Substance Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Insulin Receptor Signaling Pathway Regulation Of Kinase Activity Response To Hormone Cellular Response To Insulin Stimulus Cell Surface Receptor Signaling Pathway Response To Insulin Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Phosphorylation Innate Immune Response Defense Response Regulation Of Protein Kinase Activity Response To Stress Regulation Of Signal Transduction Regulation Of Immune System Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Blood Coagulation Hemostasis Cytokine-mediated Signaling Pathway Response To Cytokine Immune System Process Cellular Response To Cytokine Stimulus Regulation Of Protein Phosphorylation Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Response To Wounding Regulation Of Intracellular Transport ERBB Signaling Pathway Locomotion
Tagcloud ?		6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2	aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib ddr2 driven emerged gab1 harboring igf1r implicating library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly
Tagcloud (Difference) ?		6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2	aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib ddr2 driven emerged gab1 harboring igf1r implicating library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly
Tagcloud (Intersection) ?