SOCS6

Gene Name		suppressor of cytokine signaling 6
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Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Defense Response JAK-STAT Cascade Proteasomal Protein Catabolic Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of JAK-STAT Cascade Negative Regulation Of T Cell Activation
Pathways		Signaling by SCF-KIT Regulation of KIT signaling
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 18204098)
Protein-protein Interactions		22 interactors: ACVR1 BMPR1B EFEMP1 INSR IRS2 IRS4 KDM1A KIT PIK3R1 PIK3R2 RBCK1 RELA SMURF2 TCEB1 TCEB2 TGFBR1 TUBA1A TUBB4B UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		9306
HPRD ID		05491
Ensembl ID		ENSG00000170677
Uniprot IDs		O14544
PDB IDs		2VIF
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Growth Factor Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Cellular Response To Organic Substance Response To Insulin Response To Stimulus Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Viral Process ERBB Signaling Pathway Cellular Protein Modification Process Cellular Response To Stimulus Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Hormone Response To Stress Defense Response Regulation Of Cartilage Development Negative Regulation Of Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Tagcloud ?		6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2