SOCS6

Description		suppressor of cytokine signaling 6
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol
	Molecular Function	Protein Binding Signaling Adaptor Activity
	Biological Process	Defense Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of T Cell Activation
Pathways		Regulation of KIT signaling Neddylation Negative regulation of FLT3
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)
Novel Interacting Genes		1 novel interacting genes: PITRM1
Interacting Genes		38 interacting genes: ACVR1 AIRIM AMOT APPL1 AR BMPR1B CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		9306
HPRD ID		05491
Ensembl ID		ENSG00000170677
Uniprot IDs		O14544
PDB IDs		2VIF
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Migration Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Receptor Complex Protein Tyrosine Kinase Activity Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Response To Growth Factor Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Epidermal Growth Factor Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphatidylinositol 3-kinase Binding Growth Factor Binding Regulation Of Gene Expression Kinase Activity Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I ErbB-3 Class Receptor Binding Positive Regulation Of Metabolic Process Protein Modification Process ERBB2 Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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