SOCS6 and AIRIM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SOCS6	AIRIM
Description		suppressor of cytokine signaling 6	AFG2 interacting ribosome maturation factor
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Binding Signaling Adaptor Activity	Protein Binding
	Biological Process	Defense Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of T Cell Activation	Ribosome Biogenesis Ribosomal Large Subunit Biogenesis
Pathways		Regulation of KIT signaling Neddylation Negative regulation of FLT3
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)
Interacting Genes		38 interacting genes: ACVR1 AIRIM AMOT APPL1 AR BMPR1B CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2	144 interacting genes: ABI2 ADD1 ANTKMT ATP23 AVPI1 BORCS6 C1orf94 C1QTNF2 CBY2 CCDC120 CCDC125 CCDC33 CCDC88B CCHCR1 CDCA4 CEP55 CINP CRX CSNK2A1 CT55 CTAG1A CTAG1B DISC1 ECM1 ECSIT FAM217B FAM86C1P FTO GET4 GIGYF1 GOLGA2 GOLGA6A GOLGA6L9 HESX1 HOOK2 HOXC8 IHO1 IKZF1 IKZF3 INKA1 KATNAL1 KIAA0753 KIFC3 KLF15 KRT13 KRT16 KRT18 KRT19 KRT24 KRT31 KRT35 KRT40 KRT75 KRT76 KRT80 KRTAP13-3 LDOC1 LMO2 LZTS2 MBD3L1 MDM4 MEI4 MEOX1 MEOX2 MIPOL1 MKRN2 MTFR1L MTUS2 NDUFB7 NECAB2 NFKBID NME4 NUP54 NUTM2F OOEP PAX5 PAX6 PAX7 PBX4 PDE4DIP PHC2 PLK4 PNMA1 POMC POU6F2 PPP1R12C PRDM6 PRMT5 PSMB4 PUDP REL RINT1 RNF20 RNF41 RPH3AL RUSC1 SAPCD2 SDCBP SERTAD1 SERTAD2 SLAIN1 SMARCD1 SOCS6 SORBS3 SPAG5 SPMIP6 STMN3 STN1 STX11 TADA2A TASOR2 TCF12 TCF4 TEKT4 TEPSIN TFIP11 TLE5 TNNI2 TRAF1 TRIM27 TRIM42 TRIM54 TSGA10IP TTC12 TTC23 TTC23L UHMK1 USH1G USHBP1 VBP1 VGLL1 VPS52 YPEL3 ZBED1 ZBTB42 ZMAT1 ZMAT5 ZMYND12 ZNF17 ZNF20 ZNF398 ZNF420 ZNF688 ZSCAN9
Entrez ID		9306	54955
HPRD ID		05491	07918
Ensembl ID		ENSG00000170677	ENSG00000116922
Uniprot IDs		O14544	B4DRQ5 B7Z9X8 Q9NX04
PDB IDs		2VIF	8RHN
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Migration Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Receptor Complex Protein Tyrosine Kinase Activity Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Response To Growth Factor Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Epidermal Growth Factor Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphatidylinositol 3-kinase Binding Growth Factor Binding Regulation Of Gene Expression Kinase Activity Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I ErbB-3 Class Receptor Binding Positive Regulation Of Metabolic Process Protein Modification Process ERBB2 Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription	Cytoskeleton Organization Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Cytoskeleton Supramolecular Fiber Organization Intermediate Filament Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Organization Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Structural Molecule Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Centrosome Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process HMG Box Domain Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Transcription Coactivator Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Microtubule Somite Specification
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