SOCS6 and TUBB4B

Number of citations of the paper that reports this interaction (PMID 12052866)
26

Data Source:
HPRD (in vitro)

		SOCS6	TUBB4B
Gene Name		suppressor of cytokine signaling 6	tubulin, beta 4B class IVb
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm	Nucleus Cytosol Cytoskeleton Microtubule Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding MHC Class I Protein Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Defense Response JAK-STAT Cascade Proteasomal Protein Catabolic Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of JAK-STAT Cascade Negative Regulation Of T Cell Activation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Movement Of Cell Or Subcellular Component Organelle Organization Natural Killer Cell Mediated Cytotoxicity Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Spindle Assembly Protein Polymerization Transmembrane Transport
Pathways		Signaling by SCF-KIT Regulation of KIT signaling	Transport of connexons to the plasma membrane Hedgehog 'off' state Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation
Drugs			Albendazole Mebendazole Epothilone D Epothilone B
Diseases
GWAS		Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		22 interactors: ACVR1 BMPR1B EFEMP1 INSR IRS2 IRS4 KDM1A KIT PIK3R1 PIK3R2 RBCK1 RELA SMURF2 TCEB1 TCEB2 TGFBR1 TUBA1A TUBB4B UBE2D2 UBE2I WDR89 ZMIZ2	13 interactors: ACD CDKN2A DLEU1 DLST ENOX2 POT1 PSME1 SCG2 SOCS6 SOCS7 TERF1 TINF2 TUBG1
Entrez ID		9306	10383
HPRD ID		05491	04043
Ensembl ID		ENSG00000170677	ENSG00000188229
Uniprot IDs		O14544	P68371
PDB IDs		2VIF
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Growth Factor Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Cellular Response To Organic Substance Response To Insulin Response To Stimulus Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Viral Process ERBB Signaling Pathway Cellular Protein Modification Process Cellular Response To Stimulus Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Hormone Response To Stress Defense Response Regulation Of Cartilage Development Negative Regulation Of Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Negative Regulation Of Transferase Activity Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomerase Activity Negative Regulation Of Catalytic Activity Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein Kinase Activity Protein Localization To Chromosome, Telomeric Region Telomere Capping Regulation Of Catalytic Activity Negative Regulation Of Kinase Activity Positive Regulation Of Telomerase Activity Chromosome Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Growth Telomere Maintenance Via Telomerase Positive Regulation Of Proteolysis Regulation Of Proteolysis Positive Regulation Of Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Positive Regulation Of Endopeptidase Activity Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Organelle Organization RNA-dependent DNA Replication Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2
Tagcloud (Difference) ?		6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2
Tagcloud (Intersection) ?