GRAP and LAT

Number of citations of the paper that reports this interaction (PMID 9489702)
242

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GRAP	LAT
Gene Name		GRB2-related adaptor protein	linker for activation of T cells
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Immunological Synapse Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft
	Molecular Function	SH3/SH2 Adaptor Activity	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction	Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		Signaling by SCF-KIT	TCR signaling Generation of second messenger molecules GPVI-mediated activation cascade Platelet activation, signaling and aggregation Adaptive Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 21102463)
Protein-Protein Interactions		14 interactors: ARHGAP32 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 RBPMS SHC1 SOS1 TRIM21	28 interactors: CBL CD244 CD4 CD8A FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK LCK LCP2 MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2
Entrez ID		10750	27040
HPRD ID		05062	03832
Ensembl ID			ENSG00000213658
Uniprot IDs		I3L2P9 Q13588	B7WPI0 G5E9K3 O43561
PDB IDs
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Leukocyte Migration Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Defense Response Response To Growth Factor Immune System Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Blood Coagulation Signaling Hemostasis Cell Communication Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cell Migration Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Erythropoietin-mediated Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Cellular Response To Stimulus Wound Healing Positive Regulation Of Hydrolase Activity Antigen Receptor-mediated Signaling Pathway Phosphatidylinositol-mediated Signaling Cell Activation Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Intracellular Signal Transduction Cellular Response To Erythropoietin	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Innate Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Defense Response Positive Regulation Of Cell Activation Blood Coagulation Hemostasis Immune System Process Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Signal Transduction Signaling Cell Communication Platelet Activation Regulation Of Body Fluid Levels Response To Stress Wound Healing Positive Regulation Of T Cell Activation Regulation Of Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Activation Leukocyte Activation T Cell Costimulation Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Response To Wounding Positive Regulation Of Cell Adhesion Phagocytosis Lymphocyte Activation Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of T Cell Activation Leukocyte Differentiation
Tagcloud ?		associates dynamin effector endocytosis entry fyn gamma1 grb2 gtpase guanine identity jurkat lesser linker lymphocyte lymphoid mitosis p36 phospholipase phosphoproteins prominent prominently sam68 serves sh2 sh3 shc sos trafficking	abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf
Tagcloud (Difference) ?		associates dynamin effector endocytosis entry fyn gamma1 grb2 gtpase guanine identity jurkat lesser linker lymphocyte lymphoid mitosis p36 phospholipase phosphoproteins prominent prominently sam68 serves sh2 sh3 shc sos trafficking	abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf
Tagcloud (Intersection) ?