GRAP and ARHGAP32

Number of citations of the paper that reports this interaction (PubMedID 12819203)
0

Data Source:
HPRD (in vitro)

		GRAP	ARHGAP32
Description		GRB2 related adaptor protein	Rho GTPase activating protein 32
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Membrane Synapse Presynapse	Golgi Membrane Fibrillar Center Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cell Cortex Endosome Membrane Postsynaptic Density Actin Cytoskeleton Membrane Cell Projection Dendritic Spine Synapse
	Molecular Function	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Protein Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Sensory Perception Of Sound Regulation Of MAPK Cascade	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Signaling by SCF-KIT	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases
GWAS		Copper levels ( 26025379)	Intracranial aneurysm ( 30823506) Iris color (L* coordinate) ( 29109912) Macular thickness ( 30535121) Metabolite levels (5-HIAA) ( 23319000) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: ARHGAP32 DPPA4 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 PRRG4 RBPMS REL SHC1 SOS1 TOX TRIM21	33 interacting genes: ABI2 ATXN1 BCAR1 CAMK2N2 CDC42 CDH1 CDH2 CRK CRKL CTNNB1 DLG4 DZIP3 FYN GAB1 GAB2 GRAP GRB2 GRIN2A GRIN2B LHX2 MDFI MEGF10 NCK1 NCK2 NPHP1 NTRK1 PIK3R1 PLCG1 RAC1 RHOA SHC3 SRC TLE5
Entrez ID		10750	9743
HPRD ID		05062	12257
Ensembl ID		ENSG00000154016	ENSG00000134909
Uniprot IDs		I3L2P9 Q13588	A0A804HK06 A7KAX9
PDB IDs			3IUG
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction T Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Intracellular Signaling Cassette Regulation Of Immune System Process Regulation Of Immune Response Enzyme-linked Receptor Protein Signaling Pathway Activation Of Immune Response CD8 Receptor Binding Lymphocyte Activation Regulation Of Multicellular Organismal Process SH2 Domain Binding Regulation Of Intracellular Signal Transduction T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of Signal Transduction Leukocyte Activation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Erythropoietin-mediated Signaling Pathway CD4 Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of T Cell Activation Cell Activation Positive Regulation Of Immune Response Phospholipase Activator Activity Regulation Of Multicellular Organismal Development Membrane Raft T Cell Receptor Binding ERBB Signaling Pathway Leukocyte Migration Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Regulation Of Lymphocyte Activation Phospholipase Binding	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Migration Cell Surface Receptor Signaling Pathway Cell Motility Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Signal Transduction Cell-cell Junction Ephrin Receptor Signaling Pathway Regulation Of Signal Transduction Developmental Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cellular Component Biogenesis Ephrin Receptor Binding Lamellipodium Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Synapse Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Protein Kinase Binding Signaling Adaptor Activity Neuron Migration Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Actin Filament Organization Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Regulation Of Locomotion Cell-cell Junction Organization Regulation Of Lamellipodium Organization Cell Projection Organization
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