GRAP and TOX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRAP	TOX
Description		GRB2 related adaptor protein	thymocyte selection associated high mobility group box
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Membrane Synapse Presynapse	Nucleus
	Molecular Function	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Protein Binding	DNA Binding Protein Binding Chromatin DNA Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Sensory Perception Of Sound Regulation Of MAPK Cascade	Natural Killer Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment NK T Cell Lineage Commitment Leukocyte Differentiation Chromatin Organization Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Neuron Projection Development Cerebral Cortex Neuron Differentiation Lymphocyte Differentiation Positive Regulation Of Natural Killer Cell Differentiation CD4-positive, Alpha-beta T Cell Lineage Commitment CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Transcription By RNA Polymerase II Lymph Node Development Peyer's Patch Development Regulation Of Positive Thymic T Cell Selection Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Signaling by SCF-KIT
Drugs
Diseases
GWAS		Copper levels ( 26025379)	Chronotype ( 30696823) Cognitive performance ( 19734545) Height ( 31562340) High myopia ( 31816047) Hyperopia ( 25233373) Mercury levels ( 26025379) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Myopia ( 27182965 25233373) Oily fish consumption ( 32066663) Parental longevity (father's attained age) ( 29227965) Pork consumption ( 32066663) Psychological resilience (outcome-based) ( 31081985) Refractive astigmatism ( 25367360) Refractive error ( 32231278 23396134) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 33082346 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Superior temporal sulcus banks volume ( 31530798) Systolic blood pressure ( 30224653) Type 1 diabetes ( 34012112) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		18 interacting genes: ARHGAP32 DPPA4 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 PRRG4 RBPMS REL SHC1 SOS1 TOX TRIM21	6 interacting genes: BANP DMRTB1 GRAP KRTAP12-1 KRTAP26-1 ZDHHC17
Entrez ID		10750	9760
HPRD ID		05062	12113
Ensembl ID		ENSG00000154016	ENSG00000198846
Uniprot IDs		I3L2P9 Q13588	O94900
PDB IDs
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction T Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Intracellular Signaling Cassette Regulation Of Immune System Process Regulation Of Immune Response Enzyme-linked Receptor Protein Signaling Pathway Activation Of Immune Response CD8 Receptor Binding Lymphocyte Activation Regulation Of Multicellular Organismal Process SH2 Domain Binding Regulation Of Intracellular Signal Transduction T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of Signal Transduction Leukocyte Activation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Erythropoietin-mediated Signaling Pathway CD4 Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of T Cell Activation Cell Activation Positive Regulation Of Immune Response Phospholipase Activator Activity Regulation Of Multicellular Organismal Development Membrane Raft T Cell Receptor Binding ERBB Signaling Pathway Leukocyte Migration Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Regulation Of Lymphocyte Activation Phospholipase Binding	Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Keratin Filament Intermediate Filament Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity
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