GRAP and FASLG

Number of citations of the paper that reports this interaction (PubMedID 11741599)
0

Data Source:
HPRD (in vivo)

		GRAP	FASLG
Description		GRB2 related adaptor protein	Fas ligand
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Membrane Synapse Presynapse	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Protein Binding	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Sensory Perception Of Sound Regulation Of MAPK Cascade	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Intracellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Cellular Response To Type II Interferon Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by SCF-KIT	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Interleukin-4 and Interleukin-13 signaling Dimerization of procaspase-8 FasL/ CD95L signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models FOXO-mediated transcription of cell death genes TNFs bind their physiological receptors
Drugs
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Copper levels ( 26025379)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 30013184) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 24999842 25920553 20190752) Crohn's disease ( 21102463 23128233) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Psoriasis ( 28537254) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		18 interacting genes: ARHGAP32 DPPA4 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 PRRG4 RBPMS REL SHC1 SOS1 TOX TRIM21	82 interacting genes: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK CYSRT1 DAXX DLG2 DMD DNMBP DOCK4 ECM1 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB1 FYN GRAP GRAP2 GRB2 HCK IHO1 ITK ITSN2 KALRN KMT2A KRT33B KRT40 KRTAP11-1 KRTAP12-3 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NLA OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SEC23A SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TNS2 TRIP6 YES1
Entrez ID		10750	356
HPRD ID		05062	00610
Ensembl ID		ENSG00000154016	ENSG00000117560
Uniprot IDs		I3L2P9 Q13588	P48023 Q53ZZ1
PDB IDs			4MSV 5L19 5L36
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction T Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Intracellular Signaling Cassette Regulation Of Immune System Process Regulation Of Immune Response Enzyme-linked Receptor Protein Signaling Pathway Activation Of Immune Response CD8 Receptor Binding Lymphocyte Activation Regulation Of Multicellular Organismal Process SH2 Domain Binding Regulation Of Intracellular Signal Transduction T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of Signal Transduction Leukocyte Activation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Erythropoietin-mediated Signaling Pathway CD4 Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of T Cell Activation Cell Activation Positive Regulation Of Immune Response Phospholipase Activator Activity Regulation Of Multicellular Organismal Development Membrane Raft T Cell Receptor Binding ERBB Signaling Pathway Leukocyte Migration Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Regulation Of Lymphocyte Activation Phospholipase Binding	Phosphotyrosine Residue Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Antigen Receptor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Activation Of Immune Response Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Protein Tyrosine Kinase Activity Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Organization Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Binding Peptidyl-tyrosine Phosphorylation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Cell Shape Regulation Of Cell Morphogenesis Negative Regulation Of Immune System Process Regulation Of Actin Filament-based Process Positive Regulation Of Immune System Process T Cell Costimulation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Regulation Of Signal Transduction Developmental Process Phospholipase Activator Activity Endocytosis B Cell Receptor Signaling Pathway Regulation Of Cell Motility Immune System Process Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Anchoring Junction Positive Regulation Of T Cell Activation
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